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Fazekas, C; Khalil, M; Enzinger, C; Matzer, F; Fuchs, S; Fazekas, F.
No impact of adult attachment and temperament on clinical variability in patients with clinically isolated syndrome and early multiple sclerosis.
Clin Neurol Neurosurg. 2013; 115(3):293-297 Doi: 10.1016/j.clineuro.2012.05.022
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Führende Autor*innen der Med Uni Graz
Fazekas Christian
Co-Autor*innen der Med Uni Graz
Enzinger Christian
Fazekas Franz
Fuchs Siegrid
Khalil Michael
Matzer Franziska

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Objective: Attachment style and temperament could influence a stress-relapse relationship in multiple sclerosis. We therefore aimed to probe for an association of these personality-related variables with disease activity in patients with clinically isolated syndrome and early multiple sclerosis (MS). Methods: Study participants completed following psychometric instruments: Adult Attachment Scale (AAS), Temperament and Character Inventory (TCI-125), Hospital Anxiety and Depression Scale (HADS). Clinical data encompassed the expanded disability status scale (EDSS), annualized relapse rate, disease duration and therapy. Relapses and MRI data were recorded at regular outpatient visits. Results: Study participants (n = 84), 38 with a clinically isolated syndrome suggestive of MS (CIS) and 46 with relapsing remitting MS (RRMS), were assessed with a low EDSS (median 2). No significant differences concerning personality-related variables were revealed by group comparisons between CIS and RRMS and within the RRMS subgroup based on clinical measures (EDSS/year; within RRMS subgroup: annualized relapse rate). However, a higher lesion load per years of disease duration within the RRMS subgroup was associated with higher values in the temperament trait harm avoidance (p < 0.05). Conclusions: Although harm avoidance may be related to subclinical disease activity in early RRMS adult attachment and temperament do not seem to contribute to differences between CIS and RRMS or clinical variability in early multiple sclerosis. (C) 2012 Elsevier B.V. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Biological Markers -
Disease Progression -
Female -
Female -
Humans -
Magnetic Resonance Imaging -
Male -
Multiple Sclerosis - physiopathology Multiple Sclerosis - psychology
Multiple Sclerosis, Chronic Progressive - physiopathology Multiple Sclerosis, Chronic Progressive - psychology
Neuropsychological Tests -
Object Attachment -
Personality -
Personality Tests -
Psychometrics -
Recurrence -
Socioeconomic Factors -
Temperament - physiology
Young Adult -

Find related publications in this database (Keywords)
Adult attachment
Harm avoidance
Clinically isolated syndrome
Multiple sclerosis
Disease activity
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