Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Logo MUG-Forschungsportal

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid Stoffw Microb

Pichler, G; Pocivalnik, M; Riedl, R; Pichler-Stachl, E; Zotter, H; Müller, W; Urlesberger, B.
C reactive protein: impact on peripheral tissue oxygenation and perfusion in neonates.
Arch Dis Child Fetal Neonatal Ed. 2012; 97(6):F444-F448 Doi: 10.1136/archdischild-2011-300578
Web of Science PubMed FullText FullText_MUG


Führende Autor*innen der Med Uni Graz
Pichler Gerhard
Co-Autor*innen der Med Uni Graz
Müller Wilhelm
Pichler-Stachl Elisabeth
Ribitsch Mirjam
Riedl Regina
Urlesberger Berndt
Zotter Heinz

Dimensions Citations:

Plum Analytics:

Scite (citation analytics):

C reactive protein (CRP) is a sensitive marker of acute inflammation of infectious and non-infectious origin. Aim was to use near-infrared spectroscopy (NIRS) to analyse peripheral oxygenation and perfusion in term and preterm neonates with elevated CRP levels, at a time when routine haemodynamic variables are still normal. Prospective observational study. Peripheral-muscle NIRS was performed in the first week of life. Tissue-oxygenation index (TOI), mixed venous oxygenation (SvO(2)), fractional oxygen extraction (FOE), haemoglobin flow (Hbflow), oxygen delivery (DO(2)) and oxygen consumption (VO(2)) were assessed. Blood samples were taken within 3 h of the NIRS measurements. Cardiocirculatory stable term and preterm neonates with infection-related and infection-unrelated CRP elevations >10 mg/l were compared with neonates without CRP elevation. The two groups were matched for gestational and postnatal age. 33 neonates with CRP elevation (gestational age 37.7±2.9 weeks) were compared with 33 controls (gestational age 37.3±2.9 weeks). In neonates with CRP elevation, TOI (68.9±6.6%), SvO(2) (66.9±7.3%) DO(2) (39.2±16.1 µmol/100ml/min) and VO(2) (10.9±3.4 µmol/100ml/min) were significantly lower compared with controls (TOI 72.9±3.8%, SvO(2) 70.2±4.7%, DO(2) 48.8±18.4 µmol/100ml/min, VO(2) 12.3±3.8 µmol/100ml/min). There was no significant difference in any other NIRS or routine haemodynamic parameter between the two groups. Inflammatory processes with CRP elevation cause impaired peripheral oxygenation and perfusion in neonates even when routine haemodynamic variables are still normal. NIRS might offer a new non-invasive tool for the early recognition and diagnosis of infectious and non-infectious inflammatory processes.
Find related publications in this database (using NLM MeSH Indexing)
Biological Markers - blood
C-Reactive Protein - analysis
Case-Control Studies -
Hemoglobins -
Humans -
Infant, Newborn - blood
Infant, Premature - blood
Infant, Premature, Diseases - blood Infant, Premature, Diseases - metabolism
Inflammation - blood Inflammation - diagnosis Inflammation - metabolism
Muscle, Skeletal - blood supply Muscle, Skeletal - metabolism
Oxygen - metabolism
Prospective Studies -
Regional Blood Flow - physiology
Spectroscopy, Near-Infrared - methods

© Med Uni Graz Impressum