Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Kraus, T; Fischerauer, SF; Hänzi, AC; Uggowitzer, PJ; Löffler, JF; Weinberg, AM.
Magnesium alloys for temporary implants in osteosynthesis: in vivo studies of their degradation and interaction with bone.
Acta Biomater. 2012; 8(3): 1230-1238.
Doi: 10.1016/j.actbio.2011.11.008
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Kraus Tanja
- Weinberg Annelie-Martina
- Co-Autor*innen der Med Uni Graz
- Fischerauer Stefan Franz
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- Abstract:
- This study investigates the bone and tissue response to degrading magnesium pin implants in the growing rat skeleton by continuous in vivo microfocus computed tomography (ìCT) monitoring over the entire pin degradation period, with special focus on bone remodeling after implant dissolution. The influence of gas release on tissue performance upon degradation of the magnesium implant is also addressed. Two different magnesium alloys - one fast degrading (ZX50) and one slowly degrading (WZ21) - were used for evaluating the bone response in 32 male Sprague-Dawley rats. After femoral pin implantation ìCTs were performed every 4 weeks over the 24 weeks of the study period. ZX50 pins exhibited early degradation and released large hydrogen gas volumes. While considerable callus formation occurred, the bone function was not permanently harmed and the bone recovered unexpectedly quickly after complete pin degradation. WZ21 pins kept their integrity for more than 4 weeks and showed good osteoconductive properties by enhancing bone accumulation at the pin surface. Despite excessive gas formation, the magnesium pins did not harm bone regeneration. At smaller degradation rates, gas evolution remained unproblematic and the magnesium implants showed good biocompatibility. Online ìCT monitoring is shown to be suitable for evaluating materials degradation and bone response in vivo, providing continuous information on the implant and tissue performance in the same living animal.
Copyright © 2011 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. - Find related publications in this database (using NLM MeSH Indexing)
- Alloys -
- Animals -
- Bone Nails -
- Bone Regeneration -
- Femoral Fractures - metabolism
- Femur -
- Hydrogen - metabolism
- Magnesium -
- Male -
- Materials Testing -
- Rats -
- Rats, Sprague-Dawley -
- Time Factors -
- X-Ray Microtomography -
- Zinc -
- Find related publications in this database (Keywords)
- Magnesium
- Biodegradation
- Growing rat skeleton
- In vivo small animal imaging
- Microfocus computed tomography (mu CT)