Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Langsenlehner, T; Renner, W; Gerger, A; Hofmann, G; Thurner, EM; Kapp, KS; Langsenlehner, U.
Impact of VEGF gene polymorphisms and haplotypes on radiation-induced late toxicity in prostate cancer patients.
Strahlenther Onkol. 2011; 187(12):784-791
Doi: 10.1007/s00066-011-1106-4
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Langsenlehner Tanja
- Co-Autor*innen der Med Uni Graz
- Gerger Armin
- Hofmann Guenter
- Kapp Karin S.
- Langsenlehner Uwe
- Renner Wilfried
- Thurner Eva-Maria
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- Abstract:
- Vascular endothelial growth factor (VEGF) is an important determinant of microvascular permeability and angiogenesis and has been shown to be up-regulated during the late phase of radiation injury. The present prospective study was performed to evaluate the role of VEGF gene polymorphisms and haplotypes in the development of radiation-induced late side effects in prostate cancer patients. The association of VEGF gene polymorphisms and haplotypes with high-grade late rectal or urinary toxicity (defined as late toxicity EORTC/RTOG ≥ 2) was analyzed using 493 prostate cancer patients from the Austrian PROCAGENE study treated with definitive radiotherapy. Seven candidate polymorphisms in the VEGF gene were selected and determined by 5'-nuclease (TaqMan) assays. Within a median follow-up time of 48 months, 42 patients (8.6%) developed high-grade late rectal and 47 patients (9.6%) urinary toxicity, respectively. In a Kaplan-Meier analysis, carriers of the VEGF -7C > T polymorphism were at increased risk of high-grade late rectal toxicity (p = 0.003) and in a multivariate analysis including clinical and dosimetric parameters as potential confounders the VEGF -7C > T polymorphism remained a significant predictor (HR = 2.8, 95% CI 1.349-5.813; p = 0.006). Furthermore, the ATTGT haplotype formed by five polymorphisms upstream of the coding sequence demonstrated a significant association with late rectal toxicity grade ≥ 2 (p = 0.001). No significant associations were found for the remaining polymorphisms and haplotypes. We conclude that genetic variants in the VEGF gene may influence the risk of high-grade late rectal toxicity after definitive radiotherapy for prostate cancer.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Alleles -
- Follow-Up Studies -
- Genetic Carrier Screening -
- Genetic Predisposition to Disease - genetics
- Genotype -
- Haplotypes - genetics
- Humans -
- Kaplan-Meier Estimate -
- Linkage Disequilibrium -
- Male -
- Middle Aged -
- Multivariate Analysis -
- Neoplasm Grading -
- Neoplasm Staging -
- Polymorphism, Genetic - genetics
- Prospective Studies -
- Prostatic Neoplasms - pathology
- Prostatic Neoplasms - radiotherapy
- Radiation Injuries - genetics
- Rectum - radiation effects
- Urinary Bladder - radiation effects
- Vascular Endothelial Growth Factor A - genetics
- Find related publications in this database (Keywords)
- Radiotherapy
- Late toxicity
- Predictive factors
- VEGF polymorphisms
- Haplotypes