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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Hausberger, S; Steinbrugger, I; Haas, A; Rabensteiner, DF; Luger, T; Borkenstein, AF; Renner, W; Wedrich, A; El-Shabrawi, Y; Schmut, O; Weger, M.
Role of TNF-alpha-308G > A and-238G > A gene polymorphisms in patients with retinal artery occlusion
SPEKTRUM AUGENHEILKD. 2011; 25(4): 273-276. Doi: 10.1007/s00717-011-0024-2
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Führende Autor*innen der Med Uni Graz
Pinter-Hausberger Silke
Weger Martin
Co-Autor*innen der Med Uni Graz
Borkenstein Andreas
El-Shabrawi Yosuf
Haas Anton
Rabensteiner Dieter Franz
Renner Wilfried
Schmut Otto
Steinbrugger Iris
Wedrich Andreas

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BACKGROUND: Retinal artery occlusion (RAO) is a common vision-threatening disease. Several risk factors including arterial hypertension, diabetes mellitus and atherosclerosis have been identified. Atherosclerosis itself is a chronic low-grade inflammatory disease with a distinct proinflammatory cytokine profile. Among others, tumor necrosis factor alpha (TNF-alpha), a proinflammatory cytokine, contributes to atherogenesis and two TNF-alpha gene polymorphisms (TNF-alpha -308G > A and -238G > A) have previously been shown to modulate TNF-alpha expression. Consequently, the present study was set to investigate a hypothesized association between the TNF-alpha -308G > A and -238G > A polymorphisms and the presence of RAO. MATERIAL AND METHODS: Genotypes of the TNF-alpha -308G > A and -238G > A polymorphisms were determined in 240 patients with RAO and 335 control subjects. Determination of genotypes was done using 5' exonuclease assays (TaqMan). Results: Genotype distributions and allele frequencies of both TNF-alpha polymorphisms did not significantly differ between patients with RAO and control subjects (p > 0.05). Prevalences of arterial hypertension, diabetes mellitus and ever-smoking status were significantly higher in patients than among controls (arterial hypertension: 77.1% vs. 52.2%, p < 0.001; diabetes mellitus: 13.8% vs. 6.3%, p=0.002; ever-smoking status: 55.0% vs. 23.6%, p < 0.001). CONCLUSIONS: Our data suggest that both investigated TNF-alpha polymorphisms are not associated with increased risk for RAO in a Central European population.

Find related publications in this database (Keywords)
Gene polymorphism
risk factor
tumor necrosis factor alpha
retinal artery occlusion
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