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SHR Neuro Krebs Kardio Lipid

Etschmaier, K; Becker, T; Eichmann, TO; Schweinzer, C; Scholler, M; Tam-Amersdorfer, C; Poeckl, M; Schuligoi, R; Kober, A; Chirackal Manavalan, AP; Rechberger, GN; Streith, IE; Zechner, R; Zimmermann, R; Panzenboeck, U.
Adipose triglyceride lipase affects triacylglycerol metabolism at brain barriers.
J Neurochem. 2011; 119(5): 1016-1028. [OPEN ACCESS]
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Autor/innen der Med Uni Graz:
Becker Tatjana
Chirackal Manavalan Anil Paul
Etschmaier Karoline
Kober Alexandra
Panzenboeck Ute
Scholler Monika
Schuligoi Rufina
Schweinzer Cornelia Katrin
Tam-Amersdorfer Carmen
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Abstract:
Currently, little is known about the role of intracellular triacylglycerol (TAG) lipases in the brain. Adipose triglyceride lipase (ATGL) is encoded by the PNPLA2 gene and catalyzes the rate-limiting step of lipolysis. In this study, we investigated the effects of ATGL deficiency on brain lipid metabolism in vivo using an established knock-out mouse model (ATGL-ko). A moderate decrease in TAG hydrolase activity detected in ATGL-ko versus wild-type brain tissue was accompanied by a 14-fold increase in TAG levels and an altered composition of TAG-associated fatty acids in ATGL-ko brains. Oil Red O staining revealed a severe accumulation of neutral lipids associated to cerebrovascular cells and in distinct brain regions namely the ependymal cell layer and the choroid plexus along the ventricular system. In situ hybridization histochemistry identified ATGL mRNA expression in ependymal cells, the choroid plexus, pyramidal cells of the hippocampus, and the dentate gyrus. Our findings imply that ATGL is involved in brain fatty acid metabolism, particularly in regions mediating transport and exchange processes: the brain-CSF interface, the blood-CSF barrier, and the blood-brain barrier. © 2011 The Authors. Journal of Neurochemistry © 2011 International Society for Neurochemistry.
Find related publications in this database (using NLM MeSH Indexing)
Animals -
Blood-Brain Barrier - enzymology
Brain - enzymology
Disease Models, Animal -
Female -
Lipase - deficiency
Lipid Metabolism - genetics
Male -
Mice -
Mice, Inbred C57BL -
Mice, Knockout -
Triglycerides - metabolism

Find related publications in this database (Keywords)
ATGL
PNPLA2
brain barriers
cerebral lipid metabolism
fatty acid metabolism
lipid droplets
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