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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Pichler, G; Pocivalnik, M; Riedl, R; Pichler-Stachl, E; Morris, N; Zotter, H; Müller, W; Urlesberger, B.
"Multi-associations": predisposed to misinterpretation of peripheral tissue oxygenation and circulation in neonates.
Physiol Meas. 2011; 32(8):1025-1034 Doi: 10.1088/0967-3334/32/8/003
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Führende Autor*innen der Med Uni Graz
Pichler Gerhard
Co-Autor*innen der Med Uni Graz
Morris Nicholas Mark
Müller Wilhelm
Pichler-Stachl Elisabeth
Ribitsch Mirjam
Riedl Regina
Urlesberger Berndt
Zotter Heinz

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Interpretation of peripheral circulation in ill neonates is crucial but difficult. The aim was to analyse parameters potentially influencing peripheral oxygenation and circulation. In a prospective observational cohort study in 116 cardio-circulatory stable neonates, peripheral muscle near-infrared spectroscopy (NIRS) with venous occlusion was performed. Tissue oxygenation index (TOI), mixed venous oxygenation (SvO(2)), fractional oxygen extraction (FOE), fractional tissue oxygen extraction (FTOE), haemoglobin flow (Hbflow), oxygen delivery (DO(2)), oxygen consumption (VO(2)), and vascular resistance (VR) were assessed. Correlation coefficients between NIRS parameters and demographic parameters (gestational age, birth weight, age, actual weight, diameter of calf, subcutaneous adipose tissue), monitoring parameters (heart rate, arterial oxygen saturation (SaO(2)), mean blood pressure (MAP), core/peripheral temperature, central/peripheral capillary refill time) and laboratory parameters (haemoglobin concentration (Hb-blood), pCO(2)) were calculated. All demographic parameters except for Hbflow and DO(2) correlated with NIRS parameters. Heart rate correlated with TOI, SvO(2), VO(2) and VR. SaO(2) correlated with FOE/FTOE. MAP correlated with Hbflow, DO(2), VO(2) and VR. Core temperature correlated with FTOE. Peripheral temperature correlated with all NIRS parameters except VO(2). Hb-blood correlated with FOE and VR. pCO(2) levels correlated with TOI and SvO(2). The presence of multiple interdependent factors associated with peripheral oxygenation and circulation highlights the difficulty in interpreting NIRS data. Nevertheless, these findings have to be taken into account when analysing peripheral oxygenation and circulation data.
Find related publications in this database (using NLM MeSH Indexing)
Blood Circulation - physiology
Demography -
Female -
Humans -
Infant, Newborn -
Male -
Organ Specificity -
Oxygen - metabolism
Spectroscopy, Near-Infrared -

Find related publications in this database (Keywords)
near-infrared spectroscopy
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