Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Szkandera, J; Knechtel, G; Stotz, M; Hofmann, G; Langsenlehner, U; Krippl, P; Langsenlehner, T; Dehchamani, D; Samonigg, H; Renner, W; Gerger, A.
Association of hypoxia-inducible factor 1-alpha gene polymorphisms and colorectal cancer prognosis.
Anticancer Res. 2010; 30(6):2393-2397
Web of Science
PubMed
Google Scholar
- Führende Autor*innen der Med Uni Graz
- Gerger Armin
- Szkandera Joanna
- Co-Autor*innen der Med Uni Graz
- Absenger Gudrun
- Hofmann Guenter
- Langsenlehner Tanja
- Langsenlehner Uwe
- Renner Wilfried
- Samonigg Hellmut
- Stotz Michael
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Abstract:
- Background: Hypoxia inducible factor-1 (HIF-1) is the key regulator of cellular responses to hypoxia and plays a central role in tumour growth. Recently, two single nucleotide polymorphisms (SNPs) in the HIF-1alpha gene, C1772T and G1790A, were shown to cause significantly higher transcriptional activity than did the wild-type. This study aimed to investigate the effect of these SNPs on the prognosis of colorectal cancer (CRC). Patients and Methods: DNA from 336 CRC patients was genotyped. Genotypes of each polymorphism were tested for association with disease-free survival (DFS) using univariate and multivariate Cox-regression analysis. Results: Genotype frequencies were: CC 75.6%, CT 18.8% and IT 1.8% for HIF1A1 C1772T and GG 93.2%, GA 2.7% and AA 0% for G1790A. A statistically significant association between DFS and clinicopathological features was observed. However, no association was found between HIF1A1 C1772T (p=0.44; risk ratio of recurrence, RR=1.19, 95% confidence interval, CI=0.77 to 1.83) and G1790A (p=0.89; RR=0.92, 95% CI=0.29 to 2.90) polymorphisms and DFS in univariate and multivariate Cox-regression analysis. Conclusion: These results suggest that HIF1A1 C1772T and G1790A polymorphisms are not involved in the progression or metastasis of CRC.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Colorectal Neoplasms - genetics Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology
- Disease-Free Survival -
- Female -
- Genotype -
- Humans -
- Hypoxia-Inducible Factor 1, alpha Subunit - genetics
- Male -
- Middle Aged -
- Polymorphism, Single Nucleotide -
- Prognosis -
- Proportional Hazards Models -
- Find related publications in this database (Keywords)
- HIF1A1
- colorectal cancer
- polymorphisms
- prognosis