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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Hoehlschen, J; Hofreither, D; Tomin, T; Birner-Gruenberger, R.
Redox-driven cardioprotective effects of sodium-glucose co-transporter-2 inhibitors: comparative review
CARDIOVASC DIABETOL. 2023; 22(1): 101 Doi: 10.1186/s12933-023-01822-7 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
Birner-Grünberger Ruth
Tomin Tamara

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Sodium-glucose co-transporter-2 inhibitors are used in the treatment of diabetes but are also emerging as cardioprotective agents in heart diseases even in the absence of type 2 diabetes. In this paper, upon providing a short overview of common pathophysiological features of diabetes, we review the clinically reported cardio- and nephroprotective potential of sodium-glucose co-transporter-2 inhibitors currently available on the market, including Dapagliflozin, Canagliflozin, and Empagliflozin. To that end, we summarize findings of clinical trials that have initially drawn attention to the drugs' organ-protective potential, before providing an overview of their proposed mechanism of action. Since we particularly expect that their antioxidative properties will broaden the application of gliflozins from therapeutic to preventive care, special emphasis was put on this aspect.

Find related publications in this database (Keywords)
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