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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Kohshour, MO; Schulte, EC; Heilbronner, U; Budde, M; Kalman, JL; Senner, F; Heilbronner, M; Reich-Erkelenz, D; Schaupp, SK; Vogl, T; Adorjan, K; Anghelescu, IG; Arolt, V; Baune, BT; Dannlowski, U; Dietrich, D; Fallgatter, A; Figge, C; Jager, M; Lang, FU; Juckel, G; Konrad, C; Reimer, J; Reininghaus, EZ; Schmauss, M; Spitzer, C; von Hagen, M; Wiltfang, J; Zimmermann, J; Andlauer, TFM; Nothen, MM; Degenhardt, F; Forstner, AJ; Rietschel, M; Witt, SH; Fischer, A; Falkai, P; Papiol, S; Schulze, TG.
Association between mitochondria-related genes and cognitive performance in the PsyCourse Study
J AFFECT DISORDERS. 2023; 325: 1-6. Doi: 10.1016/j.jad.2023.01.013
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Co-Autor*innen der Med Uni Graz
Reininghaus Eva

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Background: Mitochondria generate energy through oxidative phosphorylation (OXPHOS). The function of key OXPHOS proteins can be altered by variation in mitochondria-related genes, which may increase the risk of mental illness. We investigated the association of mitochondria-related genes and their genetic risk burden with cognitive performance.Methods: We leveraged cross-sectional data from 1320 individuals with a severe psychiatric disorder and 466 neurotypical individuals from the PsyCourse Study. The cognitive tests analyzed were the Trail-Making Test, Verbal Digit Span Test, Digit-Symbol Test, and Multiple Choice Vocabulary Intelligence Test. Association ana-lyses between the cognitive tests, and single-nucleotide polymorphisms (SNPs) mapped to mitochondria-related genes, and their polygenic risk score (PRS) for schizophrenia (SCZ) were performed with PLINK 1.9 and R program.Results: We found a significant association (FDR-adjustedp < 0.05) in the Cytochrome C Oxidase Assembly Factor 8 (COA8) gene locus of the OXPHOS pathway with the Verbal Digit Span (forward) test. Mitochondrial PRS was not significantly associated with any of the cognitive tests.Limitations: Moderate statistical power due to relatively small sample size.Conclusions: COA8 encodes a poorly characterized mitochondrial protein involved in apoptosis. Here, this gene was associated with the Verbal Digit Span (forward) test, which evaluates short-term memory. Our results warrant replication and may lead to better understanding of cognitive impairment in mental disorders.

Find related publications in this database (Keywords)
Oxidative phosphorylation
Short-term memory
Brain disorders
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