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Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Vondra, S; Hobler, AL; Lackner, AI; Raffetseder, J; Mihalic, ZN; Vogel, A; Saleh, L; Kunihs, V; Haslinger, P; Wahrmann, M; Husslein, H; Oberle, R; Kargl, J; Haider, S; Latos, P; Schabbauer, G; Knofler, M; Ernerudh, J; Pollheimer, J.
The human placenta shapes the phenotype of decidual macrophages
CELL REP. 2023; 42(1): 111977
Doi: 10.1016/j.celrep.2022.111977
Web of Science
PubMed
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FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Kargl Julia
- Mihalic Zala Nikita
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- Abstract:
- During human pregnancy, placenta-derived extravillous trophoblasts (EVTs) invade the decidua and commu-nicate with maternal immune cells. The decidua distinguishes into basalis (decB) and parietalis (decP). The latter remains unaffected by EVT invasion. By defining a specific gating strategy, we report the accumulation of macrophages in decB. We describe a decidua basalis-associated macrophage (decBAM) population with a differential transcriptome and secretome compared with decidua parietalis-associated macrophages (dec-PAMs). decBAMs are CD11chi and efficient inducers of Tregs, proliferate in situ, and secrete high levels of CXCL1, CXCL5, M-CSF, and IL-10. In contrast, decPAMs exert a dendritic cell-like, motile phenotype char-acterized by induced expression of HLA class II molecules, enhanced phagocytosis, and the ability to acti-vate T cells. Strikingly, EVT-conditioned media convert decPAMs into a decBAM phenotype. These findings assign distinct macrophage phenotypes to decidual areas depending on placentation and further highlight a critical role for EVTs in the induction of decB-associated macrophage polarization.