Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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SHR Neuro Krebs Kardio Lipid

Trakaki, A; Sturm, GJ; Pregartner, G; Scharnagl, H; Eichmann, TO; Trieb, M; Knuplez, E; Holzer, M; Stadler, JT; Heinemann, A; Sturm, EM; Marsche, G.
Allergic rhinitis is associated with complex alterations in high-density lipoprotein composition and function.
Biochim Biophys Acta Mol Cell Biol Lipids. 2019;
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Autor/innen der Med Uni Graz:
Heinemann Akos
Holzer Michael
Knuplez Eva
Marsche Gunther
Pregartner Gudrun
Scharnagl Hubert
Sturm Eva
Sturm Gunter
Trakaki Athina
Trieb Markus
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Abstract:
Despite strong evidence that high-density lipoproteins (HDLs) modulate the immune response, the role of HDL in allergies is still poorly understood. Many patients with allergic rhinitis (AR) develop a late-phase response, characterized by infiltration of monocytes and eosinophils into the nasal submucosa. Functional impairment of HDL in AR-patients may insufficiently suppress inflammation and cell infiltration, but the effect of AR on the composition and function of HDL is not understood. We used apolipoprotein (apo) B-depleted serum as well as isolated HDL from AR-patients (n = 43) and non-allergic healthy controls (n = 20) for detailed compositional and functional characterization of HDL. Both, AR-HDL and apoB-depleted serum of AR-patients showed decreased anti-oxidative capacity and impaired ability to suppress monocyte nuclear factor-κB expression and pro-inflammatory cytokine secretion, such as interleukin (IL)-4, IL-6, IL-8, tumor necrosis factor alpha and IL-1 beta. Sera of AR-patients showed decreased paraoxonase and cholesteryl-ester transfer protein activities, increased lipoprotein-associated phospholipase A2 activity, while lecithin-cholesterol acyltransferase activity and cholesterol efflux capacity were not altered. Surprisingly, apoB-depleted serum and HDL from AR-patients showed an increased ability to suppress eosinophil effector responses upon eotaxin-2/CCL24 stimulation. Mass spectrometry and biochemical analyses showed reduced levels of apoA-I, phosphatidylcholine, but increased levels of apoA-II, triglycerides and lysophosphatidylcholine in AR-HDL. The changes in AR-HDL composition were associated with altered functional properties. In conclusion, AR alters HDL composition linked to decreased anti-oxidative and anti-inflammatory properties but improves the ability of HDL to suppress eosinophil effector responses. Copyright © 2019. Published by Elsevier B.V.

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