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SHR Neuro Krebs Kardio Lipid

Jantscher-Krenn, E; Aigner, J; Reiter, B; Köfeler, H; Csapo, B; Desoye, G; Bode, L; Van Poppel, MNM.
Evidence of Human Milk Oligosaccharides in maternal circulation already during pregnancy - a pilot study.
Am J Physiol Endocrinol Metab. 2018; 11(12):
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Autor/innen der Med Uni Graz:
Csapo Bence
Desoye Gernot
Jantscher-Krenn Evelyn
Köfeler Harald

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Plum Analytics:
Human Milk Oligosaccharides (HMOs) are bioactive glycans linked with health benefits to both, breastfed infant and lactating mother. We hypothesized that HMOs are present prior to lactation, already during pregnancy, and are influenced by maternal body composition. In a pilot study, we investigated individual and temporal variations in HMO composition and concentration in maternal serum at gestational weeks 10-14, 20-24, and 30-35 (V1, V2, and V3, respectively), and associations with maternal body composition. HMOs were quantified by HPLC and confirmed by enzymatic digest and mass spectrometry. Associations of maternal pre-pregnancy BMI, subcutaneous adipose tissue thickness (SAT) and adipokines with absolute and relative HMO concentrations were analyzed by spearman correlation. We identified 16 HMOs, and two oligosaccharides not common to human milk. HMO concentration and composition varied with gestational age and secretor status. HMO concentration increased with gestational age and changed from a predominantly sialylated profile at V1, to a more balanced fucosylated-to-sialylated ratio at V3, mostly due to a profound increase in 2'-fucosyllactose (2'FL), reflecting secretor phenotype. In secretor positive women, BMI was negatively correlated with 2'FL at V2. SAT at V1 and V2 were strongly negatively correlated with 2'FL concentrations. This pilot study shows that prenatal HMOs are present in maternal serum, suggesting roles for HMOs already during pregnancy. Our results that maternal body composition is associated with prenatal HMOs might indicate that maternal metabolism modulates HMO composition with unknown implications for maternal and fetal health already during pregnancy.

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