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SHR Neuro Krebs Kardio Lipid

Theiler-Schwetz, V; Zaufel, A; Schlager, H; Obermayer-Pietsch, B; Fickert, P; Zollner, G.
Bile acids and glucocorticoid metabolism in health and disease.
Biochim Biophys Acta Mol Basis Dis. 2019; 1865(1): 243-251.
Web of Science PubMed FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Fickert Peter
Obermayer-Pietsch Barbara
Theiler-Schwetz Verena
Zaufel Alexander
Zollner Gernot
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Abstract:
Glucocorticoids are regulators of stress response essential for survival. Liver disease can alter this homeostatic mechanism in patients with liver cirrhosis - a finding that might mirror the controversially discussed condition of critical illness related corticosteroid insufficiency. Underlying mechanisms might be shared molecular pathways in both bile acid as well as glucocorticoid metabolism at the level of synthesis, catabolism or the hypothalamus and the pituitary gland. Molecular links include the farnesoid X receptor FXR or the G protein-coupled bile acid receptor TGR5 expressed in the liver and the adrenals. In this review we sum up knowledge on the regulation of adrenal gland function and steroidogenesis, focussing on bile acids and potential alterations under cholestatic conditions, depict molecular links between glucocorticoid and bile acid metabolism and discuss the difficulties of assessment of adrenal function in humans in general and more specifically in liver diseases. Copyright © 2018 Elsevier B.V. All rights reserved.

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Relative adrenal insufficiency
Critical illness-related corticosteroid insufficiency
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