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SHR Neuro Krebs Kardio Lipid

Kronbichler, L; Tschernegg, M; Martin, AI; Schurz, M; Kronbichler, M.
Abnormal Brain Activation During Theory of Mind Tasks in Schizophrenia: A Meta-Analysis.
Schizophr Bull. 2017; 43(6): 1240-1250. [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Autor/innen der Med Uni Graz:
Lenger Melanie

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Social cognition abilities are severely impaired in schizophrenia (SZ). The current meta-analysis used foci of 21 individual studies on functional abnormalities in the schizophrenic brain in order to identify regions that reveal convergent under- or over-activation during theory of mind (TOM) tasks. Studies were included in the analyses when contrasting tasks that require the processing of mental states with tasks which did not. Only studies that investigated patients with an ICD or DSM diagnosis were included. Quantitative voxel-based meta-analyses were done using Seed-based d Mapping software. Common TOM regions like medial-prefrontal cortex and temporo-parietal junction revealed abnormal activation in schizophrenic patients: Under-activation was identified in the medial prefrontal cortex, left orbito-frontal cortex, and in a small section of the left posterior temporo-parietal junction. Remarkably, robust over-activation was identified in a more dorsal, bilateral section of the temporo-parietal junction. Further abnormal activation was identified in medial occipito-parietal cortex, right premotor areas, left cingulate gyrus, and lingual gyrus. The findings of this study suggest that SZ patients simultaneously show over- and under-activation in TOM-related regions. Especially interesting, temporo-parietal junction reveals diverging activation patterns with an under-activating left posterior and an over-activating bilateral dorsal section. In conclusion, SZ patients show less specialized brain activation in regions linked to TOM and increased activation in attention-related networks suggesting compensatory effects. © The Author 2017. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Brain Mapping -
Cerebral Cortex - diagnostic imaging
Cerebral Cortex - physiopathology
Humans -
Middle Aged -
Schizophrenia - diagnostic imaging
Schizophrenia - physiopathology
Theory of Mind - physiology
Young Adult -

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