Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Pinter, D; Enzinger, C; Gattringer, T; Eppinger, S; Niederkorn, K; Horner, S; Fandler, S; Kneihsl, M; Krenn, K; Bachmaier, G; Fazekas, F.
Prevalence and short-term changes of cognitive dysfunction in young ischemic stroke patients.
Eur J Neurol. 2018;
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Autor/innen der Med Uni Graz:
Bachmaier Gerhard
Enzinger Christian
Eppinger Sebastian
Fandler-Höfler Simon
Fazekas Franz
Gattringer Thomas
Horner Susanna
Kneihsl Markus
Niederkorn Kurt
Pinter Daniela Theresia
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Abstract:
Information on the prevalence and course of post-stroke cognitive impairment in young stroke patients is limited. We aimed to assess a consecutive sample of acute young ischemic stroke patients (18 to 55 years) for the presence and development of neuropsychological deficits. Patients prospectively underwent a comprehensive clinical and cognitive assessment, examining general cognitive function, processing speed, attention, flexibility/executive function and word fluency within the first three weeks after hospital admission (median assessment at day six) and at a three months follow-up (FU). Cognitive dysfunction was defined in comparison to age-standardized published norms. At baseline (N=114), deficits were highly prevalent in processing speed (56.0%), flexibility/executive function (49.5%), attention (46.4%) and general cognitive function (42.1%). These frequencies were comparable for those with FU assessment (N=87). In most domains, cognitive performance improved within three months, except for word fluency. However, in about one third of patients, cognitive deficits (as defined by 1.5 standard deviations below standardized mean) were still present three months after stroke. At FU, 44.0% were impaired in the domain flexibility/executive function, 35.0% in processing speed and 30.0% in attention. The high prevalence of cognitive deficits in acute young patients with ischemic stroke highlights the importance of early post-stroke cognitive assessment to capture a patient's dysfunction in a comprehensive manner and to offer adequate rehabilitation. The role of factors which promote neuropsychological deficits needs further exploration. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

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