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SHR Neuro Krebs Kardio Lipid

Saraggi, D; Salmaso, R; Zamuner, C; Munari, G; Lanza, C; Alaibac, MS; Bassetto, F; Rugge, M; Montesco, MC; Cerroni, L; Fassan, M.
Prevalence of ALK gene alterations among the spectrum of plexiform spitzoid lesions
J AM ACAD DERMATOL. 2018; 79(4): 728-735.
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Autor/innen der Med Uni Graz:
Cerroni Lorenzo
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Abstract:
Background: ALK receptor tyrosine kinase gene (ALK) rearrangements have been described in spitzoid lesions with a plexiform growth pattern. Objective: To investigate the prevalence of ALK alterations in a large series of spitzoid lesions. Methods: ALK immunohistochemical and fluorescence in situ hybridization analyses of 78 spitzoid plexiform lesions including 41 Spitz nevi, 29 atypical Spitz tumors (ASTs), and 8 spitzoid melanomas. Results: ALK immunohistochemical staining was observed in 14.6% of Spitz nevi (6 of 41) and 13.8% of ASTs (4 of 29); the spitzoid melanomas were ALK negative. Fluorescence in situ hybridization confirmed ALK translocation in 9 cases and amplification in 1 case. In 2 of the translocated cases it was possible to determine the fusion partner gene (ie, tropomyosin 3 gene [TPM3] or dynactin 1 gene [DCTN1]). Of the 4 cases of AST examined, 2 carried the B-Raf proto-oncogene, serine/threonine kinase gene (BRAF) V600E mutation. The 10 patients had a mean age of 18.7 years (range, 1-39) and a female predominance (female-to-male ratio, 7: 3). Seven lesions arose on the extremities; the 2 lesions occurring in infants were located on the face. The lesions' mean diameter was 6.2 mm (range, 3-13), and their mean Breslow thickness was 1.83 mm (range, 0.6-3.6). The results of sentinel node biopsy were negative in 2 ASTs. Limitations: BRAF status was tested in only 4 of 10 samples because of the limited amount of material. Conclusion: ALK alterations characterize a significant subset of spitzoid lesions.

Find related publications in this database (Keywords)
ALK
atypical Spitz tumor
plexiform melanocytic lesions
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