Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Fissolo, N; Cervera-Carles, L; Villar Guimerans, LM; Lleó, A; Clarimón, J; Drulovic, J; Dujmovic, I; Voortman, M; Khalil, M; Gil, E; Navarro, L; Álvarez-Cermeño, JC; Montalban, X; Comabella, M.
Cerebrospinal fluid mitochondrial DNA levels in patients with multiple sclerosis.
Mult Scler. 2018; 1352458518786055-1352458518786055
PubMed FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Khalil Michael
Voortman Margarete
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Abstract:
The role of cerebrospinal fluid (CSF) mitochondrial DNA (mtDNA) levels as biomarker in multiple sclerosis (MS) is unknown. We determined CSF mtDNA levels in a cohort of 237 individuals, including patients with MS and clinically isolated syndrome (CIS), inflammatory and non-inflammatory neurological controls, and cognitively healthy controls (HC). mtDNA concentration was measured by droplet digital polymerase chain reaction. CSF mtDNA levels were increased in all pathological conditions compared with HC, though no differences were observed between relapse-onset and progressive MS clinical forms, CIS patients and neurological controls. These findings do not support the determination of CSF mtDNA levels as a useful biomarker in MS clinical practice.

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