Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Logo MUG-Forschungsportal

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Dobsak, T; Heimel, P; Tangl, S; Schwarze, UY; Schett, G; Gruber, R.
Impaired periodontium and temporomandibular joints in tumour necrosis factor-α transgenic mice.
J Clin Periodontol. 2017; 44(12): 1226-1235.
Web of Science PubMed FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Schwarze Uwe Yacine
Altmetrics:

Dimensions Citations:

Plum Analytics:
Abstract:
Tumour necrosis factor (TNF)-α is a pathological factor causing the characteristic symptoms of periodontal disease and rheumatoid arthritis. In this study, we describe the phenotypes of human TNF-α transgenic mice (hTNFtg) with respect to their periodontium and the temporomandibular joint (TMJ). Periodontal structures, TMJ and skull shape of hTNFtg mice and wild-type (WT) littermates were assessed by microcomputed tomography, automated segmentation, geometric morphometrics and histologic ground sections. We show that hTNFtg mice have an eroded lamina dura and reduced periodontal ligament space compared to (WT) littermates. Transgenic mice further exhibit severe destruction of the TMJ. Geometric morphometrics revealed that hTNFtg mice have a more laterally positioned TMJ with a concomitantly enlarged zygomatic process. Mandibular and maxillary teeth occluded properly. Our findings suggest that chronic inflammation in hTNFtg mice causes destructive changes of the periodontium and the TMJ. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Find related publications in this database (Keywords)
geometric morphometrics
inflammation
mouse
periodontium
resorption
rheumatoid arthritis
temporomandibular joints
transgenic
tumour necrosis factor-
© Meduni Graz Impressum