Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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SHR Neuro Krebs Kardio Lipid

Proneth, A; Schnitzbauer, AA; Schenker, P; Wunsch, A; Rauchfuss, F; Arbogast, H; Manekeller, S; Nadalin, S; Heise, M; Ströhlein, MA; Banas, B; Schemmer, P; Becker, T; Bechstein, WO; Pascher, A; Viebahn, R; Geissler, EK; Schlitt, HJ; Farkas, SA.
Extended Pancreas Donor Program - The EXPAND Study A prospective multicenter trial testing the use of pancreas donors over age 50.
Transplantation. 2018;
PubMed FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Schemmer Peter
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Abstract:
Pancreas transplantation is the only curative treatment option for patients with juvenile diabetes. Organ shortage and restrictive allocation criteria are the main reasons for increasing waitlists leading to severe morbidity and mortality. We designed a study to increase the donor pool with extended donor criteria (EDC) organs (donor age 50-60 years or BMI 30-34kg/m). Utilization of EDC organs required the implementation of a new allocation system within Eurotransplant. The study was a prospective, multicenter, two-armed trial. The primary endpoint was pancreas function after 3 months. Rejection episodes, kidney function and waitlist time were secondary endpoints. Patients receiving an EDC organ were study-group patients; recipients of standard organs were control-group patients. Follow-up was 1 year. 79 patients were included in 12 German centers; 18 received EDC organs and 61 received standard organs. Recipient demographics were similar. Mean EDC donor age was 51.4 ± 5 years versus 31.7 ± 12 in the control group. Insulin-free graft survival was 83.3% for EDC and 67.2% for standard organs (p=0.245) after 3 months. 1-year pancreas survival was 83.3% and 83.5% in the EDC versus standard group. 1-year kidney allograft survival was approximately 94% in both groups. Rejection episodes and morbidity were similar. EXPAND shows in a prospective trial that selected EDC organs of donors aged >50 years can be used with outcomes similar to standard-criteria organs, therefore showing potential to reduce organ shortage and waiting times. This study substantiates the full implementation of EDC organs in a pancreas allocation system.

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