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SHR Neuro Krebs Kardio Lipid

Kohl Schwartz, AS; Wölfler, MM; Mitter, V; Rauchfuss, M; Haeberlin, F; Eberhard, M; von Orelli, S; Imthurn, B; Imesch, P; Fink, D; Leeners, B.
Endometriosis, especially mild disease: a risk factor for miscarriages.
Fertil Steril. 2017; 108(5):806-814
Web of Science PubMed FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Wölfler Monika
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Abstract:
To investigate the prevalence of miscarriage in women with endometriosis (WwE) compared with disease-free control women (CW). Cross-sectional analysis nested in a retrospective observational study (n = 940). Hospitals and associated private practices. Previously pregnant women (n = 268) within reproductive age in matched pairs. Retrospective analysis of surgical reports and self-administered questionnaires. Rate of miscarriage, subanalysis for fertility status (≤12 vs. >12 months' time to conception), endometriosis stages (revised American Society of Reproductive Medicine classification [rASRM] I/II vs. III/IV) and phenotypic localizations (superficial peritoneal, ovarian, and deep infiltrating endometriosis). The miscarriage rate was higher in WwE (35.8% [95% confidence interval 29.6%-42.0%]) compared with CW (22.0% [16.7%-27.0%]); adjusted incidence risk ratio of 1.97 (95% CI 1.41-2.75). This remained significant in subfertile WwE (50.0% [40.7%-59.4%]) vs. CW (25.8% [8.5%-41.2%]) but not in fertile WwE (24.5% [16.3%-31.6%]) vs. CW (21.5% [15.9%-26.8%]). The miscarriage rate was higher in women with milder forms (rASRM I/II 42.1% [32.6%-51.4%] vs. rASRM III/IV 30.8% [22.6%-38.7%], compared with 22.0% [16.7%-27.0%] in CW), and in women with superficial peritoneal endometriosis (42.0% [32.0%-53.9%]) compared with ovarian endometriosis (28.6% [17.7%-38.7%]) and deep infiltrating endometriosis (33.9% [21.2%-46.0%]) compared with CW (22.0% [16.7%-27.0%]). Mild endometriosis, as in superficial lesions, is related to a great extent of inflammatory disorder, possibly leading to defective folliculogenesis, fertilization, and/or implantation, presenting as increased risk of miscarriage. NCT02511626. Copyright © 2017 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing)
Abortion, Spontaneous - diagnosis
Abortion, Spontaneous - epidemiology
Abortion, Spontaneous - physiopathology
Adolescent -
Adult -
Cross-Sectional Studies -
Endometriosis - diagnosis
Endometriosis - epidemiology
Endometriosis - physiopathology
Europe - epidemiology
Female -
Fertility -
Humans -
Infertility, Female - diagnosis
Infertility, Female - epidemiology
Infertility, Female - physiopathology
Middle Aged -
Odds Ratio -
Pregnancy -
Prevalence -
Retrospective Studies -
Risk Assessment -
Risk Factors -
Severity of Illness Index -
Young Adult -

Find related publications in this database (Keywords)
Endometriosis
infertility
miscarriage
pregnancy outcome
superficial peritoneal endometriosis
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