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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Berger, N; Allerkamp, H; Wadsack, C.
Serine Hydrolases in Lipid Homeostasis of the Placenta-Targets for Placental Function?
Int J Mol Sci. 2022; 23(12): 6851 Doi: 10.3390/ijms23126851 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz

Berger Natascha

Wadsack Christian

Co-Autor*innen der Med Uni Graz

Allerkamp Hanna

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Abstract:

The metabolic state of pregnant women and their unborn children changes throughout pregnancy and adapts to the specific needs of each gestational week. These adaptions are accomplished by the actions of enzymes, which regulate the occurrence of their endogenous substrates and products in all three compartments: mother, placenta and the unborn. These enzymes determine bioactive lipid signaling, supply, and storage through the generation or degradation of lipids and fatty acids, respectively. This review focuses on the role of lipid-metabolizing serine hydrolases during normal pregnancy and in pregnancy-associated pathologies, such as preeclampsia, gestational diabetes mellitus, or preterm birth. The biochemical properties of each class of lipid hydrolases are presented, with special emphasis on their role in placental function or dysfunction. While, during a normal pregnancy, an appropriate tonus of bioactive lipids prevails, dysregulation and aberrant signaling occur in diseased states. A better understanding of the dynamics of serine hydrolases across gestation and their involvement in placental lipid homeostasis under physiological and pathophysiological conditions will help to identify new targets for placental function in the future.

Find related publications in this database (Keywords)

serine hydrolases

lipases

placenta

placental metabolism

pregnancy disorders

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