Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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SHR Neuro Krebs Kardio Lipid

Linortner, P; Fazekas, F; Schmidt, R; Ropele, S; Pendl, B; Petrovic, K; Loitfelder, M; Neuper, C; Enzinger, C.
White matter hyperintensities alter functional organization of the motor system.
NEUROBIOL AGING. 2012; 33(1): 197.e1-197.e9.
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Autor/innen der Med Uni Graz:
Enzinger Christian
Fazekas Franz
Koini Marisa
Linortner Patricia
Pendl Barbara
Petrovic Katja Elisabeth
Ropele Stefan
Schmidt Reinhold
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Abstract:
Severe white matter hyperintensities (WMH) represent cerebral small vessel disease and predict functional decline in the elderly. We used fMRI to test if severe WMH impact on functional brain network organization even before clinical dysfunction. Thirty healthy right-handed/footed subjects (mean age, 67.8 ± 7.5 years) underwent clinical testing, structural MRI and fMRI at 3.0T involving repetitive right ankle and finger movements. Data were compared between individuals with absent or punctuate (n = 17) and early confluent or confluent (n = 13) WMH. Both groups did not differ in mobility or cognition data. On fMRI, subjects with severe WMH demonstrated excess activation in the pre-supplementary motor area (SMA), frontal, and occipital regions. Activation differences were noted with ankle movements only. Pre-SMA activation correlated with frontal WMH load for ankle but not finger movements. With simple ankle movements and no behavioral deficits, elderly subjects with severe WMH demonstrated pre-SMA activation, usually noted with complex tasks, as a function of frontal WMH load. This suggests compensatory activation related to disturbance of frontosubcortical circuits. Copyright © 2012 Elsevier Inc. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing)
Aged -
Aged, 80 and over -
Ankle - physiopathology
Cerebral Small Vessel Diseases - diagnosis
Female -
Fingers - physiopathology
Frontal Lobe - pathology
Humans -
Magnetic Resonance Imaging -
Male -
Middle Aged -
Motor Cortex - pathology
Movement -
Occipital Lobe - pathology

Find related publications in this database (Keywords)
White matter hyperintensities
Aging
Motor system
fMRI
SMA
Pre-SMA
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