Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Andino, L; Cagle, PT; Murer, B; Lu, L; Popper, HH; Galateau-Salle, F; Sienko, AE; Barrios, R; Zander, DS.
Pleuropulmonary desmoid tumors: immunohistochemical comparison with solitary fibrous tumors and assessment of beta-catenin and cyclin D1 expression.
Arch Pathol Lab Med. 2006; 130(10):1503-1509 [OPEN ACCESS]
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Autor/innen der Med Uni Graz:
Popper Helmuth
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Abstract:
CONTEXT: Desmoid tumors arising in the lung and pleura are extremely rare and can resemble other, more common neoplasms native to these sites. Alterations of the adenomatous polyposis coli/beta-catenin pathway have been detected in sporadic desmoid tumors and have been associated with nuclear accumulation of beta-catenin and overexpression of cyclin D1. OBJECTIVE: To analyze the expression of beta-catenin and cyclin D1 in desmoid tumors and solitary fibrous tumors (SFTs), and to compare the utilities of these substances for distinguishing between these entities with those of other, more commonly used stains. DESIGN: Formalin-fixed, paraffin-embedded sections of 4 desmoid tumors (1 pulmonary, 1 pleural, 2 pleural/chest wall), and 5 benign and 6 malignant SFTs of the pleura were immunostained for beta-catenin, cyclin D1, ALK1, CD34, vimentin, desmin, smooth muscle actin, muscle-specific actin, S100, and pancytokeratin. Staining intensity and the percentage of stained tumor cells were assessed semiquantitatively. RESULTS: Diffuse moderate or strong nuclear staining for beta-catenin was found in all desmoid tumors, 4 of 5 benign SFTs, and 2 of 6 malignant SFTs. All cases except 1 benign SFT showed concurrent cytoplasmic staining. Nuclear and cytoplasmic cyclin D1 staining was increased in all groups. The best distinction between desmoid tumors and SFTs was provided by CD34 (desmoid tumors, 0/4; SFTs, 8/11) and smooth muscle actin (desmoid tumors, 4/4; SFTs, 0/11). CONCLUSIONS: Our findings suggest that alterations in the adenomatous polyposis coli/beta-catenin pathway and cyclin D1 dysregulation may contribute to the pathogenesis of pleuropulmonary desmoid tumors and SFTs. CD34 and smooth muscle actin stains are particularly useful for differentiating between pleuropulmonary desmoid tumors and SFTs.
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Actins - metabolism
Adult - metabolism
Aged - metabolism
Antigens, CD34 - metabolism
Cell Nucleus - metabolism
Child, Preschool - metabolism
Cyclin D1 - metabolism
Cytoplasm - metabolism
Diagnosis, Differential - metabolism
Female - metabolism
Fibromatosis, Aggressive - metabolism
Humans - metabolism
Immunohistochemistry - metabolism
Leiomyoma - metabolism
Lung Neoplasms - metabolism
Male - metabolism
Middle Aged - metabolism
Muscle, Smooth - metabolism
Pleural Neoplasms - metabolism
Staining and Labeling - metabolism
beta Catenin - metabolism

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