Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Paar, M; Seifried, K; Cvirn, G; Buchmann, A; Khalil, M; Oettl, K.
Redox State of Human Serum Albumin in Multiple Sclerosis: A Pilot Study.
Int J Mol Sci. 2022; 23(24):
Doi: 10.3390/ijms232415806
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- Führende Autor*innen der Med Uni Graz
- Khalil Michael
- Öttl Karl
- Paar Margret
- Co-Autor*innen der Med Uni Graz
- Buchmann Arabella
- Cvirn Gerhard
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- Abstract:
- Like in many other pathologies, oxidative stress is involved in the development of neurodegenerative disorders. Human serum albumin (HSA) is the main protein in different body fluids including cerebrospinal fluid (CSF). By its redox state in terms of cysteine-34, albumin serves as marker for oxidative burden. We aimed to evaluate the redox state of HSA in patients with multiple sclerosis in serum and CSF in comparison to controls to identify possible correlations with disease activity and severity. Samples were stored at -70 °C until analysis by HPLC for the determination of albumin redox state in terms of the fractions of human mercaptalbumin (HMA), human nonmercaptalbumin1 (HNA1), and human nonmercaptalbumin2 (HNA2). Albumin in CSF showed significantly higher fractions of the reduced form HMA and decreased HNA1 and HNA2. There was no difference between albumin redox states in serum of patients and controls. In CSF of patients HNA2 showed a trend to higher fractions compared to controls. Albumin redox state in serum was associated with physical disability in remission while albumin redox state in CSF was related to disease activity. Thus, albumin redox state in serum and CSF of patients in relation to disease condition merits further investigation.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Serum Albumin, Human - metabolism
- Pilot Projects - administration & dosage
- Multiple Sclerosis - administration & dosage
- Serum - metabolism
- Oxidation-Reduction - administration & dosage
- Find related publications in this database (Keywords)
- human serum albumin
- human mercaptalbumin
- human nonmercaptalbumin
- human cerebrospinal fluid albumin
- albumin redox state
- multiple sclerosis
- biomarker
- cerebrospinal fluid (CSF)
- serum