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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Hofer, E; Pirpamer, L; Langkammer, C; Tinauer, C; Seshadri, S; Schmidt, H; Schmidt, R.
Heritability of R2* iron in the basal ganglia and cortex.
Aging (Albany NY). 2022; 14(16):6415-6426 Doi: 10.18632/aging.204212 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Führende Autor*innen der Med Uni Graz
Hofer Edith
Schmidt Reinhold
Co-Autor*innen der Med Uni Graz
Langkammer Christian
Pirpamer Lukas
Schmidt Helena
Tinauer Christian Gerhard

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BACKGROUND: While iron is essential for normal brain functioning, elevated concentrations are commonly found in neurodegenerative diseases and are associated with impaired cognition and neurological deficits. Currently, only little is known about genetic and environmental factors that influence brain iron concentrations. METHODS: Heritability and bivariate heritability of regional brain iron concentrations, assessed by R2* relaxometry at 3 Tesla MRI, were estimated with variance components models in 130 middle-aged to elderly participants of the Austrian Stroke Prevention Family Study. RESULTS: Heritability of R2* iron ranged from 0.46 to 0.82 in basal ganglia and from 0.65 to 0.76 in cortical lobes. Age and BMI explained up to 12% and 9% of the variance of R2* iron, while APOE ε4 carrier status, hypertension, diabetes, hypercholesterolemia, sex and smoking explained 5% or less. The genetic correlation of R2* iron among basal ganglionic nuclei and among cortical lobes ranged from 0.78 to 0.87 and from 0.65 to 0.97, respectively. R2* rates in basal ganglia and cortex were not genetically correlated. CONCLUSIONS: Regional brain iron concentrations are mainly driven by genetic factors while environmental factors contribute to a certain extent. Brain iron levels in the basal ganglia and cortex are controlled by distinct sets of genes.
Find related publications in this database (using NLM MeSH Indexing)
Aged - administration & dosage
Basal Ganglia - administration & dosage
Brain - administration & dosage
Cerebral Cortex - diagnostic imaging
Humans - administration & dosage
Iron - administration & dosage
Magnetic Resonance Imaging - administration & dosage
Middle Aged - administration & dosage

Find related publications in this database (Keywords)
brain iron
magnetic resonance imaging
genetic correlation
genetic and environmental factors
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