Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid Stoffw Microb

Hofer, E; Pirpamer, L; Langkammer, C; Tinauer, C; Seshadri, S; Schmidt, H; Schmidt, R.
Heritability of R2* iron in the basal ganglia and cortex.
Aging (Albany NY). 2022; 14(16):6415-6426 Doi: 10.18632/aging.204212 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

 

Führende Autor*innen der Med Uni Graz

Hofer Edith

Schmidt Reinhold

Co-Autor*innen der Med Uni Graz

Langkammer Christian

Pirpamer Lukas

Schmidt Helena

Tinauer Christian Gerhard

Altmetrics:

Dimensions Citations:

Plum Analytics:

Scite (citation analytics):

Abstract:

BACKGROUND: While iron is essential for normal brain functioning, elevated concentrations are commonly found in neurodegenerative diseases and are associated with impaired cognition and neurological deficits. Currently, only little is known about genetic and environmental factors that influence brain iron concentrations. METHODS: Heritability and bivariate heritability of regional brain iron concentrations, assessed by R2* relaxometry at 3 Tesla MRI, were estimated with variance components models in 130 middle-aged to elderly participants of the Austrian Stroke Prevention Family Study. RESULTS: Heritability of R2* iron ranged from 0.46 to 0.82 in basal ganglia and from 0.65 to 0.76 in cortical lobes. Age and BMI explained up to 12% and 9% of the variance of R2* iron, while APOE ε4 carrier status, hypertension, diabetes, hypercholesterolemia, sex and smoking explained 5% or less. The genetic correlation of R2* iron among basal ganglionic nuclei and among cortical lobes ranged from 0.78 to 0.87 and from 0.65 to 0.97, respectively. R2* rates in basal ganglia and cortex were not genetically correlated. CONCLUSIONS: Regional brain iron concentrations are mainly driven by genetic factors while environmental factors contribute to a certain extent. Brain iron levels in the basal ganglia and cortex are controlled by distinct sets of genes.

Find related publications in this database (using NLM MeSH Indexing)

Aged - administration & dosage

Basal Ganglia - administration & dosage

Brain - administration & dosage

Cerebral Cortex - diagnostic imaging

Humans - administration & dosage

Iron - administration & dosage

Magnetic Resonance Imaging - administration & dosage

Middle Aged - administration & dosage

Find related publications in this database (Keywords)

brain iron

heritability

magnetic resonance imaging

genetic correlation

genetic and environmental factors

© Med Uni Graz • Impressum