Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Schrom, S; Hebesberger, T; Wallner, SA; Anders, I; Richtig, E; Brandl, W; Hirschmugl, B; Garofalo, M; Bernecker, C; Schlenke, P; Kashofer, K; Wadsack, C; Aigelsreiter, A; Heitzer, E; Riedl, S; Zweytick, D; Kretschmer, N; Richtig, G; Rinner, B.
MUG Mel3 Cell Lines Reflect Heterogeneity in Melanoma and Represent a Robust Model for Melanoma in Pregnancy.
Int J Mol Sci. 2021; 22(21):
Doi: 10.3390/ijms222111318
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- Führende Autor*innen der Med Uni Graz
- Rinner Beate
- Schrom Silke
- Co-Autor*innen der Med Uni Graz
- Aigelsreiter Ariane
- Anders Ines
- Bernecker Claudia
- Brandl Waltraud Theresia
- Hebesberger Thomas
- Heitzer Ellen
- Hirschmugl Birgit
- Kashofer Karl
- Kretschmer Nadine
- Richtig Erika
- Richtig Georg
- Riedl Sabrina
- Schlenke Peter
- Wadsack Christian
- Wallner Stefanie Angela
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- Abstract:
- Melanomas are aggressive tumors with a high metastatic potential and an increasing incidence rate. They are known for their heterogeneity and propensity to easily develop therapy-resistance. Nowadays they are one of the most common cancers diagnosed during pregnancy. Due to the difficulty in balancing maternal needs and foetal safety, melanoma is challenging to treat. The aim of this study was to provide a potential model system for the study of melanoma in pregnancy and to illustrate melanoma heterogeneity. For this purpose, a pigmented and a non-pigmented section of a lymph node metastasis from a pregnant patient were cultured under different conditions and characterized in detail. All four culture conditions exhibited different phenotypic, genotypic as well as tumorigenic properties, and resulted in four newly established melanoma cell lines. To address treatment issues, especially in pregnant patients, the effect of synthetic human lactoferricin-derived peptides was tested successfully. These new BRAF-mutated MUG Mel3 cell lines represent a valuable model in melanoma heterogeneity and melanoma pregnancy research. Furthermore, treatment with anti-tumor peptides offers an alternative to conventionally used therapeutic options-especially during pregnancy.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult - administration & dosage
- Animals - administration & dosage
- Cell Culture Techniques - methods
- Cell Line - administration & dosage
- Cell Line, Tumor - administration & dosage
- Female - administration & dosage
- Humans - administration & dosage
- Lactoferrin - pharmacology
- Lymphatic Metastasis - administration & dosage
- Melanoma - drug therapy, genetics, metabolism
- Mice - administration & dosage
- Mice, Inbred NOD - administration & dosage
- Pregnancy - administration & dosage
- Primary Cell Culture - administration & dosage
- Proto-Oncogene Proteins B-raf - genetics
- Skin Neoplasms - pathology
- Xenograft Model Antitumor Assays - methods
- Find related publications in this database (Keywords)
- melanoma
- tumor heterogeneity
- pregnancy
- anti-tumor peptides
- in vitro model