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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Lindner, AK; Pichler, M; Thurnher, M; Pichler, R.
Targeting c-Met to Improve Immune Checkpoint Inhibition in Metastatic Renal Cell Carcinoma.
Eur Urol. 2022; 81(1): 1-2. Doi: 10.1016/j.eururo.2021.10.025
Web of Science PubMed FullText FullText_MUG

 

Co-Autor*innen der Med Uni Graz

Pichler Martin

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Abstract:

c-Met inhibition has direct antitumor effects on proliferation, angiogenesis, and metastasis, and indirect antitumor effects via prevention of the induction of immunosuppressive mechanisms (PD-L1, TGFβ, IDO1). c-Met inhibition is key to overcome resistance to immune checkpoint inhibition and to maximize the efficacy of immunotherapy.

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