Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid Stoffw Microb

Fissolo, N; Cervera-Carles, L; Villar Guimerans, LM; Lleó, A; Clarimón, J; Drulovic, J; Dujmovic, I; Voortman, M; Khalil, M; Gil, E; Navarro, L; Álvarez-Cermeño, JC; Montalban, X; Comabella, M.
Cerebrospinal fluid mitochondrial DNA levels in patients with multiple sclerosis.
Mult Scler. 2019; 25(11):1535-1538 Doi: 10.1177/1352458518786055
Web of Science PubMed FullText FullText_MUG

 

Co-Autor*innen der Med Uni Graz

Khalil Michael

Voortman Margarete Maria

Altmetrics:

Dimensions Citations:

Plum Analytics:

Scite (citation analytics):

Abstract:

The role of cerebrospinal fluid (CSF) mitochondrial DNA (mtDNA) levels as biomarker in multiple sclerosis (MS) is unknown. We determined CSF mtDNA levels in a cohort of 237 individuals, including patients with MS and clinically isolated syndrome (CIS), inflammatory and non-inflammatory neurological controls, and cognitively healthy controls (HC). mtDNA concentration was measured by droplet digital polymerase chain reaction. CSF mtDNA levels were increased in all pathological conditions compared with HC, though no differences were observed between relapse-onset and progressive MS clinical forms, CIS patients and neurological controls. These findings do not support the determination of CSF mtDNA levels as a useful biomarker in MS clinical practice.

Find related publications in this database (Keywords)

Mitochondrial DNA

cerebrospinal fluid

multiple sclerosis

droplet digital PCR

© Med Uni Graz • Impressum