Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid Stoffw Microb

Frauscher, B; Artinger, K; Kirsch, AH; Aringer, I; Moschovaki-Filippidou, F; Kétszeri, M; Schabhüttl, C; Rainer, PP; Schmidt, A; Stojakovic, T; Fahrleitner-Pammer, A; Rosenkranz, AR; Eller, P; Eller, K.
A New Murine Model of Chronic Kidney Disease-Mineral and Bone Disorder.
Int J Endocrinol. 2017; 2017(3):1659071-1659071 Doi: 10.1155/2017/1659071 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Führende Autor*innen der Med Uni Graz
Eller Philipp
Frauscher Bianca
Co-Autor*innen der Med Uni Graz
Aringer Ida
Artinger Katharina
Eller Kathrin
Fahrleitner-Pammer Astrid
Ketszeri Mate Csaba
Kirsch Alexander
Rainer Peter
Rosenkranz Alexander
Schabhüttl Corinna
Schmidt Albrecht
Stojakovic Tatjana

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Chronic kidney disease (CKD) is associated with mineral and bone disorder (MBD), which is the main cause of the extensively increased cardiovascular mortality in the CKD population. We now aimed to establish a new murine experimental CKD-MBD model. Dilute brown non-Agouti (DBA/2) mice were fed with high-phosphate diet for 4 (HPD4) or 7 (HPD7) days, then with standard chow diet (SCD) and subsequently followed until day 84. They were compared to DBA/2 mice maintained on SCD during the whole study period. Both 4 and 7 days HPD-fed mice developed phosphate nephropathy with tubular atrophy, interstitial fibrosis, decreased glomerular filtration rate, and increased serum urea levels. The abdominal aorta of HPD-treated mice showed signs of media calcification. Histomorphometric analysis of HPD-treated mice showed decreased bone volume/tissue volume, low mineral apposition rate, and low bone formation rate as compared to SCD-fed mice, despite increased parathyroid hormone levels. Overall, the observed phenotype was more pronounced in the HPD7 group. In summary, we established a new, noninvasive, and therefore easy to perform reproducible CKD-MBD model, which showed media calcification, secondary hyperparathyroidism, and low-turnover bone disease.

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