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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Smolle, MA; Leithner, A; Posch, F; Szkandera, J; Liegl-Atzwanger, B; Pichler, M.
MicroRNAs in Different Histologies of Soft Tissue Sarcoma: A Comprehensive Review.
Int J Mol Sci. 2017; 18(9): Doi: 10.3390/ijms18091960 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz

Pichler Martin

Smolle Maria Anna

Co-Autor*innen der Med Uni Graz

Leithner Andreas

Liegl-Atzwanger Bernadette

Posch Florian

Szkandera Joanna

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Abstract:

Soft tissue sarcomas (STS) constitute a rare tumour entity comprising over 50 histological subtypes. MicroRNAs (miRNAs) are short non-protein coding RNA molecules that regulate gene expression by targeting the 3'-untranslated region of messenger RNAs. They are involved in a variety of human diseases, including malignancies, such as endometrial cancer, osteosarcoma, bronchial carcinoma and breast cancer. In STS, various miRNAs are differentially expressed, thus contributing to development, progression and invasion. Therefore, the aim of the present review is to summarise current knowledge on the role of miRNAs in STS. Furthermore, the potential role of miRNAs as diagnostic, prognostic and predictive biomarkers is discussed.

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Biomarkers, Tumor -

Fibrosarcoma - metabolism

Gene Expression Regulation, Neoplastic -

Hemangiosarcoma - metabolism

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Leiomyosarcoma - metabolism

Liposarcoma - metabolism

MicroRNAs - classification

MicroRNAs - genetics

MicroRNAs - metabolism

Neurilemmoma - metabolism

Prognosis -

RNA, Messenger - genetics

Rhabdomyosarcoma - metabolism

Sarcoma - diagnosis

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Sarcoma, Synovial - metabolism

Find related publications in this database (Keywords)

soft tissue sarcoma

microRNAs

tumourigenesis

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