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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Cătană, CS; Pichler, M; Giannelli, G; Mader, RM; Berindan-Neagoe, I.
Non-coding RNAs, the Trojan horse in two-way communication between tumor and stroma in colorectal and hepatocellular carcinoma.
Oncotarget. 2017; 8(17):29519-29534 Doi: 10.18632/oncotarget.15706 [OPEN ACCESS]
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Co-Autor*innen der Med Uni Graz

Pichler Martin

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Abstract:

In a continuous and mutual exchange of information, cancer cells are invariably exposed to microenvironment transformation. This continuous alteration of the genetic, molecular and cellular peritumoral stroma background has become as critical as the management of primary tumor progression events in cancer cells. The communication between stroma and tumor cells within the extracellular matrix is one of the triggers in colon and liver carcinogenesis. All non- codingRNAs including long non-coding RNAs, microRNAs and ultraconserved genes play a critical role in almost all cancers and are responsible for the modulation of the tumor microenvironment in several malignant processes such as initiation, progression and dissemination. This review details the involvement of non codingRNAs in the evolution of human colorectal carcinoma and hepatocellular carcinoma in relationship with the microenvironment. Recent research has shown that a considerable number of dysregulated non- codingRNAs could be valuable diagnostic and prognostic biomarkers in cancer. Therefore, more in-depth knowledge of the role non- codingRNAs play in stroma-tumor communication and of the complex regulatory mechanisms between ultraconserved genes and microRNAs supports the validation of future effective therapeutic targets in patients suffering from hepatocellular and colorectal carcinoma, two distinctive entities which share quite a lot common non-coding RNAs.

Find related publications in this database (using NLM MeSH Indexing)

Carcinoma, Hepatocellular - genetics

Carcinoma, Hepatocellular - pathology

Colorectal Neoplasms - genetics

Colorectal Neoplasms - pathology

Disease Progression -

Humans -

Liver Neoplasms - genetics

Liver Neoplasms - pathology

RNA, Long Noncoding - metabolism

Tumor Microenvironment -

Find related publications in this database (Keywords)

tumor microenvironment

microRNA

long non-coding RNA

CRC

HCC

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