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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Aigelsreiter, A; Neumann, J; Pichler, M; Halasz, J; Zatloukal, K; Berghold, A; Douschan, P; Rainer, F; Stauber, R; Haybaeck, J; Denk, H; Lackner, C.
Hepatocellular carcinomas with intracellular hyaline bodies have a poor prognosis.
Liver Int. 2017; 37(4):600-610 Doi: 10.1111/liv.13325
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Führende Autor*innen der Med Uni Graz

Aigelsreiter Ariane

Lackner Karoline

Co-Autor*innen der Med Uni Graz

Berghold Andrea

Denk Helmut

Douschan Philipp

Haybäck Johannes

Pichler Martin

Rainer Florian

Stauber Rudolf

Zatloukal Kurt

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Abstract:

Mallory-Denk bodies (MDBs) and intracellular hyaline bodies (IHBs) are cytoplasmic inclusions found in a subset of hepatocellular carcinoma (HCC). MDBs are mainly composed of the intermediate filament proteins keratin (K) 8 and K18, the cellular stress- and adapter-protein sequestosome 1/p62 (p62) and ubiquitin, whereas IHBs consist of p62 and/or ubiquitin. Of note, cytoplasmic inclusions containing p62 can serve as markers of suppressed autophagy, which in turn has been associated with poor prognosis. The aim of this study was to evaluate the prognostic significance of p62-containing MDB and IHB in patients with HCC. Ninety resected HCCs were assessed by H&E histology for MDB or IHB, and their presence was confirmed by immunohistochemistry using K8/18, p62 and ubiquitin antibodies. The prognostic impact of inclusions was assessed using Kaplan-Meier and multivariate Cox proportional model. Mallory-Denk bodies and/or IHB were found in about 50% of HCC. Both types of inclusions were seen in 21%, MDB only in 19% and IHB only in 10% of cases. The presence of MDB in tumours was associated with the steatohepatitic variant of HCC, which also showed fatty change, ballooning of tumour cells, MDBs, inflammation and pericellular fibrosis (P<.001). In contrast, IHBs were not associated with steatohepatitic morphology but were associated with significantly shorter overall survival (P=.006). Multivariate analysis revealed macroscopic vascular invasion (P=.045) and presence of IHB in HCC cells (P=.005) as independently associated with overall survival. Intracellular hyaline bodies and macroscopic vascular invasion identify a subset of HCC patients with poor prognosis. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Find related publications in this database (using NLM MeSH Indexing)

Adaptor Proteins, Signal Transducing - metabolism

Aged -

Austria -

Autophagy -

Carcinoma, Hepatocellular - metabolism

Carcinoma, Hepatocellular - mortality

Female -

Hepatocytes - metabolism

Humans -

Immunohistochemistry -

Inclusion Bodies - metabolism

Keratin-18 - metabolism

Keratin-8 - metabolism

Liver - metabolism

Liver - pathology

Liver Neoplasms - metabolism

Liver Neoplasms - mortality

Male -

Middle Aged -

Multivariate Analysis -

Prognosis -

Retrospective Studies -

Sequestosome-1 Protein - metabolism

Survival Analysis -

Find related publications in this database (Keywords)

autophagy

hepatocellular carcinoma

intracellular hyaline body

Mallory-Denk body

prognosis

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