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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Grübler, MR; Gaksch, M; Kienreich, K; Verheyen, N; Schmid, J; Ó, Hartaigh, BW; Richtig, G; Scharnagl, H; Meinitzer, A; Pieske, B; Fahrleitner-Pammer, A; März, W; Tomaschitz, A; Pilz, S.
Effects of Vitamin D Supplementation on Plasma Aldosterone and Renin-A Randomized Placebo-Controlled Trial.
J Clin Hypertens (Greenwich). 2016; 18(7):608-13 Doi: 10.1111/jch.12825 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz

Grübler Martin

Co-Autor*innen der Med Uni Graz

Fahrleitner-Pammer Astrid

Keppel Martin

Kienreich Katharina

März Winfried

Meinitzer Andreas

Pieske Burkert Mathias

Pilz Stefan

Richtig Georg

Scharnagl Hubert

Schmid Johannes

Tomaschitz Andreas

Verheyen Nicolas Dominik

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Abstract:

Increasing evidence describes a possible interplay between vitamin D insufficiency with increased aldosterone. The authors sought to evaluate the effect of vitamin D supplementation on plasma aldosterone concentration (PAC) in patients with hypertension and 25-hydroxyvitamin D[25(OH)D] insufficiency. The Styrian Vitamin D Hypertension Trial was a single-center, double-blind, placebo-controlled randomized clinical trial conducted from 2011 to 2014. Two hundred patients with arterial hypertension and 25(OH)D levels <30 ng/mL were enrolled. Study participants were randomized to receive either 2800 IU of vitamin D3 or placebo. The present investigation is a post hoc analysis using analysis of covariance adjusting for baseline differences. A total of 188 participants (mean±standard deviation age, 60.1±11.3 years; 47% women; 25(OH)D, 21.2±5.6 ng/mL) completed the trial. Mean differences between baseline and follow-up PAC in the control and intervention arm were +3.3 ng/dL and +0.9 ng/dL, respectively (P=.04). The findings indicate that vitamin D3 supplementation significantly decreases PAC in patients with arterial hypertension and 25(OH)D insufficiency.

Find related publications in this database (using NLM MeSH Indexing)

Aged - administration & dosage

Aldosterone - blood

Dietary Supplements - administration & dosage

Double-Blind Method - administration & dosage

Female - administration & dosage

Humans - administration & dosage

Hypertension - blood, complications

Male - administration & dosage

Middle Aged - administration & dosage

Renin - blood

Treatment Outcome - administration & dosage

Vitamin D - administration & dosage, pharmacology

Vitamin D Deficiency - diet therapy, metabolism

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