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Landsmann, B; Pinter, D; Pirker, E; Pichler, G; Schippinger, W; Weiss, EM; Mathie, G; Gattringer, T; Fazekas, F; Enzinger, C.
An exploratory intervention study suggests clinical benefits of training in chronic stroke to be paralleled by changes in brain activity using repeated fMRI.
Clin Interv Aging. 2016; 11(3):97-103 Doi: 10.2147/CIA.S95632 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz

Landsmann Barbara

Pinter Daniela Theresia

Co-Autor*innen der Med Uni Graz

Enzinger Christian

Fazekas Franz

Gattringer Thomas

Pirker Eva

Schippinger Walter

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Abstract:

Previous studies demonstrated changes in sensorimotor network activation over time after stroke that have been interpreted as partly compensatory. Locomotor and balance trainings may improve both mobility and cognition even in chronic stroke and thereby impact on cerebral activation patterns. We here aimed at testing these assumptions in an exploratory study to inform subsequent larger intervention studies. Eight patients (73.3±4.4 years) with a chronic lacunar stroke (mean interval 3.7 years after the acute event with a range from 2 to 4 years) and residual leg paresis leading to gait disturbance received a guided 5-week training focusing on mobility, endurance, and coordination. Before and afterward, they underwent clinical, neuropsychological, and gait assessments and brain MRI at 3 T including a functional ankle movement paradigm. Sixteen healthy controls (HCs; 68.8±5.4 years) followed the same protocol without intervention. After training, patients had improved in mobility, memory, and delayed recall of memory. While cerebral activations in HC remained completely unaltered, patients showed increased activations in the right precentral gyrus, the right and left superior frontal gyri, and the right frontal lobe, with bipedal ankle movements after training. In this exploratory study of chronic stroke, we found not only significant effects of physical training on mobility but also distinct aspects of cognition already with a small number of highly selected patients. These improvements were paralleled by alterations in cerebral activity possibly reflecting neuronal plasticity. Larger studies including randomization are needed.

Find related publications in this database (using NLM MeSH Indexing)

Aged -

Aged, 80 and over -

Case-Control Studies -

Chronic Disease -

Cognition -

Exercise Therapy - methods

Female -

Frontal Lobe - physiopathology

Functional Laterality -

Gait -

Humans -

Magnetic Resonance Imaging -

Male -

Memory -

Movement -

Neuronal Plasticity -

Recovery of Function -

Stroke Rehabilitation -

Treatment Outcome -

Find related publications in this database (Keywords)

mobility

cognition

lacunar stroke

training

rehabilitation

neuronal plasticity

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