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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Freudenberger, P; Petrovic, K; Sen, A; Töglhofer, AM; Fixa, A; Hofer, E; Perl, S; Zweiker, R; Seshadri, S; Schmidt, R; Schmidt, H.
Fitness and cognition in the elderly: The Austrian Stroke Prevention Study.
Neurology. 2016; 86(5):418-424 Doi: 10.1212/WNL.0000000000002329 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Führende Autor*innen der Med Uni Graz
Freudenberger Paul
Schmidt Helena
Co-Autor*innen der Med Uni Graz
Birkl-Töglhofer Anna Maria
Fixa André
Hofer Edith
Perl Sabine
Petrovic Katja-Elisabeth
Schmidt Reinhold
Sen Abhijit
Zweiker Robert

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To investigate whether greater cardiorespiratory fitness is associated with better global and domain-specific cognitive function. We investigated 877 participants (aged 65 ± 7 years, 55% women) of the Austrian Stroke Prevention Study. For cardiorespiratory fitness, the maximum oxygen consumption (V̇o2max) was calculated based on weight and maximum and resting heart rate on a treadmill test (mL·kg(-1)·min(-1)). A test battery assessing memory (Bäumler's Lern-und Gedächtnistest), executive function (Wisconsin Card Sorting Test, Trail Making Test-Part B, Digit Span Backward, Alters Konzentrationstest, a computerized complex reaction time task) and motor skills (Purdue Pegboard Test) was administered. Summary measures for cognitive domains and for global cognition were calculated. White matter lesions, lacunes, and brain atrophy were assessed using MRI. Higher V̇o2max was associated with better global (B = 0.024; p = 0.000) and domain-specific cognitive function (memory B = 0.026, p = 0.000; executive function B = 0.009, p = 0.003; motor skills B = 0.012, p = 0.018) after adjustment for age, sex, education years, and Ca(2+) channel antagonists or β-blockers. White matter lesions, lacunes, or brain atrophy did not mediate the effect (p > 0.05 for all mediators). The interactions of V̇o2max with age, overweight, and APOE ε4 on cognition were not statistically significant (p > 0.05 for all interaction terms) with the exception of a modulating effect of body mass index on V̇o2max in the memory domain. Higher V̇o2max is associated with better global cognitive function and with better performance in the cognitive domains of memory, executive function, and motor skills in the middle-aged and elderly. The association is not mediated by the presence of white matter lesions, lacunes, and brain atrophy. © 2016 American Academy of Neurology.
Find related publications in this database (using NLM MeSH Indexing)
Aged -
Aged - epidemiology
Cognition - physiology
Cohort Studies -
Cross-Sectional Studies -
Exercise Test - methods
Female -
Humans -
Magnetic Resonance Imaging - methods
Male -
Middle Aged -
Oxygen Consumption - physiology
Physical Fitness - physiology
Stroke - diagnosis
Stroke - epidemiology
Stroke - prevention & control

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