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Tillema, JM; Hulst, HE; Rocca, MA; Vrenken, H; Steenwijk, MD; Damjanovic, D; Enzinger, C; Ropele, S; Tedeschi, G; Gallo, A; Ciccarelli, O; Rovira, A; Montalban, X; de Stefano, N; Stromillo, ML; Filippi, M; Barkhof, F; MAGNIMS Study Group.
Regional cortical thinning in multiple sclerosis and its relation with cognitive impairment: A multicenter study.
Mult Scler. 2016; 22(7):901-909 Doi: 10.1177/1352458515607650
Web of Science PubMed FullText FullText_MUG


Co-Autor*innen der Med Uni Graz
Enzinger Christian
Ropele Stefan

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The objectives of this paper are to compare in a multicenter setting patterns of regional cortical thickness in patients with relapsing-remitting multiple sclerosis (RRMS) and cognitive impairment (CI) and those cognitively preserved (CP), and explore the relationship between cortical thinning and cognitive performance. T1-weighted isotropic brain scans were collected at 3T from seven European centers in 60 RRMS patients and 65 healthy controls (HCs). Patients underwent clinical and neuropsychological examinations. Cortical thickness (CTh) measures were calculated using FreeSurfer (failing in four) and both lobar and vertex-based general linear model (GLM) analyses were compared between study groups. Twenty (36%) MS patients were classified as CI. Mean global CTh was smaller in RRMS patients compared to HCs (left 2.43 vs. 2.53 mm, right 2.44 vs. 2.54 mm, p < 0.001). Multivariate GLM regional analysis showed significantly more temporal thinning in CI compared to CP patients. Verbal memory scores correlated to regional cortical thinning in the insula whereas visual memory scores correlated to parietal thinning. This multicenter study showed mild global cortical thinning in RRMS. The extent of thinning is less pronounced than previously reported. Only subtle regional differences between CI and CP patients were observed, some of which related to specific cognitive domains. © The Author(s), 2015.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Case-Control Studies -
Cerebral Cortex - diagnostic imaging
Cerebral Cortex - physiopathology
Cognition -
Cognitive Dysfunction - diagnosis
Cognitive Dysfunction - etiology
Cognitive Dysfunction - physiopathology
Cognitive Dysfunction - psychology
Cross-Sectional Studies -
Europe -
Female -
Humans -
Linear Models -
Magnetic Resonance Imaging -
Male -
Memory -
Middle Aged -
Multiple Sclerosis, Relapsing-Remitting - complications
Multiple Sclerosis, Relapsing-Remitting - diagnostic imaging
Multiple Sclerosis, Relapsing-Remitting - physiopathology
Multiple Sclerosis, Relapsing-Remitting - psychology
Neuropsychological Tests -
Predictive Value of Tests -
Risk Factors -

Find related publications in this database (Keywords)
Multiple sclerosis
cortical atrophy
cognitive impairment
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