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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Rocca, MA; Amato, MP; De Stefano, N; Enzinger, C; Geurts, JJ; Penner, IK; Rovira, A; Sumowski, JF; Valsasina, P; Filippi, M; MAGNIMS Study Group.
Clinical and imaging assessment of cognitive dysfunction in multiple sclerosis.
Lancet Neurol. 2015; 14(3):302-317 Doi: 10.1016/S1474-4422(14)70250-9
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Co-Autor*innen der Med Uni Graz
Enzinger Christian

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In patients with multiple sclerosis (MS), grey matter damage is widespread and might underlie many of the clinical symptoms, especially cognitive impairment. This relation between grey matter damage and cognitive impairment has been lent support by findings from clinical and MRI studies. However, many aspects of cognitive impairment in patients with MS still need to be characterised. Standardised neuropsychological tests that are easy to administer and sensitive to disease-related abnormalities are needed to gain a better understanding of the factors affecting cognitive performance in patients with MS than exists at present. Imaging measures of the grey matter are necessary, but not sufficient to fully characterise cognitive decline in MS. Imaging measures of both lesioned and normal-appearing white matter lend support to the hypothesis of the existence of an underlying disconnection syndrome that causes clinical symptoms to trigger. Findings on cortical reorganisation support the contribution of brain plasticity and cognitive reserve in limiting cognitive deficits. The development of clinical and imaging biomarkers that can monitor disease development and treatment response is crucial to allow early identification of patients with MS who are at risk of cognitive impairment. Copyright © 2015 Elsevier Ltd. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing)
Cognition Disorders - diagnosis
Cognition Disorders - epidemiology
Cognition Disorders - psychology
Cross-Sectional Studies -
Diagnostic Imaging - methods
Humans -
Longitudinal Studies -
Magnetic Resonance Imaging - methods
Multiple Sclerosis - diagnosis
Multiple Sclerosis - epidemiology
Multiple Sclerosis - psychology
Neuropsychological Tests -

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