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Kraitsy, K; Uecal, M; Grossauer, S; Bruckmann, L; Pfleger, F; Ropele, S; Fazekas, F; Gruenbacher, G; Patz, S; Absenger, M; Porubsky, C; Smolle-Juettner, F; Tezer, I; Molcanyi, M; Fasching, U; Schaefer, U.
Repetitive long-term hyperbaric oxygen treatment (HBOT) administered after experimental traumatic brain injury in rats induces significant remyelination and a recovery of sensorimotor function.
PLoS One. 2014; 9(5): e97750-e97750. Doi: 10.1371/journal.pone.0097750 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz

Kraitsy Klaus

Schäfer Ute

Co-Autor*innen der Med Uni Graz

Absenger-Novak Markus

Bruckmann Lukas

Fazekas Franz

Grossauer Stefan

Grünbacher Gerda

Molcanyi Marek

Patz Silke

Porubsky Christian

Ropele Stefan

Smolle-Juettner Freyja-Maria

Ücal Muammer

Zefferer Ulrike

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Abstract:

Cells in the central nervous system rely almost exclusively on aerobic metabolism. Oxygen deprivation, such as injury-associated ischemia, results in detrimental apoptotic and necrotic cell loss. There is evidence that repetitive hyperbaric oxygen therapy (HBOT) improves outcomes in traumatic brain-injured patients. However, there are no experimental studies investigating the mechanism of repetitive long-term HBOT treatment-associated protective effects. We have therefore analysed the effect of long-term repetitive HBOT treatment on brain trauma-associated cerebral modulations using the lateral fluid percussion model for rats. Trauma-associated neurological impairment regressed significantly in the group of HBO-treated animals within three weeks post trauma. Evaluation of somatosensory-evoked potentials indicated a possible remyelination of neurons in the injured hemisphere following HBOT. This presumption was confirmed by a pronounced increase in myelin basic protein isoforms, PLP expression as well as an increase in myelin following three weeks of repetitive HBO treatment. Our results indicate that protective long-term HBOT effects following brain injury is mediated by a pronounced remyelination in the ipsilateral injured cortex as substantiated by the associated recovery of sensorimotor function.

Find related publications in this database (using NLM MeSH Indexing)

Animals -

Brain - pathology

Brain Injuries - pathology

Evoked Potentials -

Hyperbaric Oxygenation -

Male -

Myelin Sheath - physiology

Psychomotor Performance -

Rats -

Rats, Sprague-Dawley -

Recovery of Function -

Time Factors -

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