Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Aigelsreiter, AM; Aigelsreiter, A; Wehrschuetz, M; Ress, AL; Koller, K; Salzwimmer, M; Gerger, A; Schauer, S; Bauernhofer, T; Pichler, M.
Loss of the putative tumor suppressor protein spinophilin is associated with poor prognosis in head and neck cancer.
Hum Pathol. 2014; 45(4):683-690 Doi: 10.1016/j.humpath.2013.11.014
Web of Science PubMed FullText FullText_MUG


Führende Autor*innen der Med Uni Graz
Aigelsreiter Alena Maria
Aigelsreiter Ariane
Co-Autor*innen der Med Uni Graz
Bauernhofer Thomas
Friedrich Michaela
Gerger Armin
Koller Karin
Lembeck Anna Lena
Pichler Martin
Schauer Silvia
Wehrschütz Martin

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The putative tumor suppressor protein spinophilin has been recently involved in the pathogenesis of lung, liver, and other types of cancer. Previous studies also indicate that a loss of spinophilin in combination with functional impairment of p53 drives tumor progression. To date, no data exist about the role of spinophilin in head and neck squamous cell carcinoma (HNSCC). In the present study, we evaluated spinophilin and p53 expression by immunohistochemistry in 85 patients with nonmetastatic HNSCC. Kaplan-Meier curves and multivariate Cox proportional models were used to define the prognostic relevance of spinophilin for patients with HNSCC. Overall, immunoreactivity for spinophilin was reduced in 40 tumors (47%). Nine cases (10.5%) showed complete loss of spinophilin. Kaplan-Meier curve analysis demonstrated that reduced spinophilin expression is associated with poor overall survival (P = .022). Concomitant analysis of spinophilin and p53 further showed that patients with reduced spinophilin expression and nuclear p53 staining have a significantly decreased overall survival (hazard ratio, 1.96; 95% confidence interval, 1.06-3.61; P = .030). In conclusion, the combination of reduced spinophilin expression and nuclear p53 staining indicates a poor prognosis in HNSCC patients. Based on our results, spinophilin might play a previously unrecognized role in the pathogenesis of HNSCC. © 2014.
Find related publications in this database (using NLM MeSH Indexing)
Aged -
Biomarkers, Tumor - analysis
Carcinoma, Squamous Cell - metabolism
Carcinoma, Squamous Cell - mortality
Carcinoma, Squamous Cell - pathology
Female -
Head and Neck Neoplasms - metabolism
Head and Neck Neoplasms - mortality
Head and Neck Neoplasms - pathology
Humans -
Immunohistochemistry -
Kaplan-Meier Estimate -
Male -
Microfilament Proteins - analysis
Microfilament Proteins - biosynthesis
Middle Aged -
Nerve Tissue Proteins - analysis
Nerve Tissue Proteins - biosynthesis
Prognosis -
Proportional Hazards Models -
Squamous Cell Carcinoma of Head and Neck -
Tumor Suppressor Protein p53 - analysis
Tumor Suppressor Protein p53 - biosynthesis

Find related publications in this database (Keywords)
Head and neck cancer
Novel tumor suppressor protein
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