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Adzemovic, MZ; Zeitelhofer, M; Hochmeister, S; Gustafsson, SA; Jagodic, M.
Efficacy of vitamin D in treating multiple sclerosis-like neuroinflammation depends on developmental stage.
Exp Neurol. 2013; 249(12):39-48 Doi: 10.1016/j.expneurol.2013.08.002 [OPEN ACCESS]
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Hochmeister Sonja

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The association of vitamin D deficiency with higher prevalence, relapse rate and progression of multiple sclerosis (MS) has stimulated great interest in using vitamin D supplementation as a preventative measure and even a therapy for established MS. However, there is a considerable lack of evidence when it comes to an age/developmental stage-dependent efficacy of vitamin D action and a time-window for the most effective prophylactic treatment remains unclear. We studied the effect of vitamin D supplementation in myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE), an animal model of MS, at three different developmental stages in rats. Supplementation treatment was initiated: i) prior to gestation and maintained throughout pre- and early postnatal development (gestation and lactation); ii) after weaning, throughout juvenile/adolescence period and iii) in adult age. We observed a marked attenuation of EAE in juvenile/adolescent rats reflected in a less severe CNS inflammation and demyelination, accompanied by a lower amount of IFN-γ producing MOG-specific T cells. Moreover, the cytokine expression pattern in these rats reflected a more anti-inflammatory phenotype of their peripheral immune response. However, the same supplementation regimen failed to improve the disease outcome both in adult rats and in rats treated during pre- and early post-natal development. Our data demonstrate a developmental stage-dependent efficiency of vitamin D to ameliorate neuroinflammation, suggesting that childhood and adolescence should be the target for the most effective preventive treatment.
Find related publications in this database (using NLM MeSH Indexing)
Aging - physiology
Animals -
Dietary Supplements -
Disease Progression -
Encephalomyelitis, Autoimmune, Experimental - drug therapy
Female -
Inflammation - drug therapy
Multiple Sclerosis - drug therapy
Rats -
Treatment Outcome -
Vitamin D - administration & dosage

Find related publications in this database (Keywords)
Vitamin D supplementation
Developmental stages
Multiple sclerosis
T cell response
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