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Hutterer, GC; Pichler, M; Chromecki, TF; Strini, KA; Klatte, T; Pummer, K; Remzi, M; Mannweiler, S; Zigeuner, R.
Tumour-associated macrophages might represent a favourable prognostic indicator in patients with papillary renal cell carcinoma.
Histopathology. 2013; 63(3):309-315 Doi: 10.1111/his.12163
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Führende Autor*innen der Med Uni Graz

Hutterer Georg

Pichler Martin

Co-Autor*innen der Med Uni Graz

Chromecki Thomas

Mannweiler Sebastian

Pummer Karl

Strini Karin

Zigeuner Richard

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Abstract:

Tumour-associated macrophages (TAM) have been reported to be regulators of progression in various human cancers. We evaluated the prognostic relevance of TAM in a large series of patients with papillary renal cell carcinoma (PRCC). The impact of TAM on cancer-specific survival (CSS) in 177 patients with PRCC was assessed using the Kaplan-Meier method and log-rank test. A multivariate Cox regression analysis was performed with respect to CSS. The presence of TAM was noted in 112 of 177 (63%) tumours and was associated statistically significantly with favourable pathological parameters, including low pathological T stage, node-negative tumours, low tumour grade, absence of vascular invasion and papillary subtype (all P < 0.05), respectively. Five-year CSS probabilities for patients with TAM-positive tumours were 93.5%, compared with 72.5% in patients with TAM-negative tumours, respectively (P < 0.001). Multivariate analysis revealed node-positive tumours, distant metastases and UICC stage (I versus II-IV) as independent predictors of death from PRCC, whereas the presence of TAM was associated independently with favourable outcome (hazard ratio = 0.45, 95% confidence interval 0.24-0.84, P = 0.012). The presence of TAM was shown independently to reduce the risk of death from cancer by 55%. The presence of TAM should therefore become part of routine pathology reporting in PRCC. © 2013 John Wiley & Sons Ltd.

Find related publications in this database (using NLM MeSH Indexing)

Adult -

Aged -

Aged, 80 and over -

Carcinoma, Renal Cell - mortality

Cohort Studies -

Female -

Humans -

Kaplan-Meier Estimate -

Kidney Neoplasms - mortality

Macrophages - immunology

Male -

Middle Aged -

Multivariate Analysis -

Neoplasm Grading -

Neoplasm Staging -

Prognosis -

Proportional Hazards Models -

Retrospective Studies -

Young Adult -

Find related publications in this database (Keywords)

macrophages

papillary renal cell carcinoma

prognosis

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