Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid Stoffw Microb

Kienreich, K; Grubler, M; Tomaschitz, A; Schmid, J; Verheyen, N; Rutters, F; Dekker, JM; Pilz, S.
Vitamin D, arterial hypertension & cerebrovascular disease.
Indian J Med Res. 2013; 137(4):669-679 [OPEN ACCESS]
Web of Science PubMed PUBMED Central


Führende Autor*innen der Med Uni Graz
Kienreich Katharina
Pilz Stefan
Co-Autor*innen der Med Uni Graz
Grübler Martin
Schmid Johannes
Tomaschitz Andreas
Verheyen Nicolas Dominik

Dimensions Citations:

Plum Analytics:
Vitamin D is mainly derived from endogenous ultraviolet-B induced vitamin D synthesis in the skin, and the current high prevalence of vitamin D deficiency can, therefore, largely be attributed to lifestyle related low sunlight exposure. Regulation of bone and mineral metabolism is a classic vitamin D effect, but the identification of the vitamin D receptor (VDR) in almost all human cells suggests a role for vitamin D also in extra-skeletal diseases. Experimental studies demonstrated several antihypertensive and vascular protective effects of vitamin D, such as suppression of the renin angiotensin aldosterone system, beneficial modulation of classic cardiovascular risk factors, and anti-atherosclerotic properties including improvements of endothelial function. Additional neuroprotective actions of vitamin D have also been reported. In line with this, epidemiological studies have largely shown that vitamin D deficiency is an independent risk factor for arterial hypertension and strokes. Data from randomized controlled trials (RCTs) are, however, limited and less promising, with currently no confirmation that vitamin D reduces stroke incidence. Whereas some RCTs suggest that vitamin D supplementation might modestly reduce blood pressure, this has not been consistently observed in all studies. It is, therefore, premature to recommend vitamin D supplementation for the prevention and treatment of arterial hypertension and stroke. Nevertheless, the fact that patients with arterial hypertension and cerebrovascular disease are at a relatively high risk of vitamin D deficiency, and therewith associated musculoskeletal diseases can serve as a rationale for the evaluation, prevention and treatment of vitamin D deficiency in these patients.
Find related publications in this database (using NLM MeSH Indexing)
Bone and Bones - metabolism
Bone and Bones - pathology
Cerebrovascular Disorders - complications
Cerebrovascular Disorders - metabolism
Cerebrovascular Disorders - pathology
Humans -
Hypertension - complications
Hypertension - metabolism
Hypertension - pathology
Receptors, Calcitriol - genetics
Renin-Angiotensin System -
Risk Factors -
Vitamin D - genetics
Vitamin D - metabolism
Vitamin D Deficiency - complications
Vitamin D Deficiency - genetics
Vitamin D Deficiency - pathology

Find related publications in this database (Keywords)
Arterial hypertension
blood pressure
vitamin D
© Med Uni Graz Impressum