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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Adams, HH; Cavalieri, M; Verhaaren, BF; Bos, D; van der Lugt, A; Enzinger, C; Vernooij, MW; Schmidt, R; Ikram, MA.
Rating Method for Dilated Virchow-Robin Spaces on Magnetic Resonance Imaging.
Stroke. 2013; 44(6):1732-1735 Doi: 10.1161/STROKEAHA.111.000620 [OPEN ACCESS]
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Co-Autor*innen der Med Uni Graz

Cavalieri Margherita

Enzinger Christian

Schmidt Reinhold

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Abstract:

Background and Purpose-Dilated Virchow-Robin spaces are an emerging neuroimaging biomarker, but their assessment on MRI needs standardization. Methods-We developed a rating method for dilated Virchow-Robin spaces in 4 brain regions (centrum semiovale, basal ganglia, hippocampus, and mesencephalon) and tested its reliability in a total of 125 MRI scans from 2 population-based studies. Six investigators with varying levels of experience performed the ratings. Intraclass correlation coefficients were calculated to determine intra- and interrater reliability. Results-Intrarater reliability was excellent for all 4 regions (intraclass correlation coefficient, >0.8). Interrater reliability was excellent for the centrum semiovale and hippocampus (intraclass correlation coefficient, >0.8) and good for the basal ganglia and mesencephalon (intraclass correlation coefficient, 0.6-0.8). This did not differ between the cohorts or experience levels. Conclusions-We describe a reliable rating method that can facilitate pathogenic and prognostic research on dilated Virchow-Robin spaces using MRI.

Find related publications in this database (using NLM MeSH Indexing)

Aged -

Basal Ganglia - pathology

Brain - pathology

Cerebrovascular Disorders - pathology

Cognition Disorders - pathology

Dementia - pathology

Extracellular Fluid -

Female -

Hippocampus - pathology

Humans -

Magnetic Resonance Imaging - methods

Male -

Mesencephalon - pathology

Middle Aged -

Observer Variation -

Prognosis -

Reproducibility of Results -

Severity of Illness Index -

Find related publications in this database (Keywords)

epidemiology

MRI

population-based study

Virchow-Robin spaces

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