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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Stadlbauer, V; Stiegler, P; Taeubl, P; Sereinigg, M; Puntschart, A; Bradatsch, A; Curcic, P; Seifert-Held, T; Zmugg, G; Stojakovic, T; Leopold, B; Blattl, D; Horki, V; Mayrhauser, U; Wiederstein-Grasser, I; Leber, B; Jürgens, G; Tscheliessnigg, K; Hallström, S.
Energy status of pig donor organs after ischemia is independent of donor type.
J Surg Res. 2013; 180(2):356-367 Doi: 10.1016/j.jss.2012.05.025
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Führende Autor*innen der Med Uni Graz

Hallström Seth

Stadlbauer-Köllner Vanessa

Stiegler Philipp

Co-Autor*innen der Med Uni Graz

Blattl Daniela

Curcic Pero

Höller Vera

Jürgens Günther

Leber Bettina

Leopold-Posch Barbara

Mayrhauser Ursula

Puntschart Andreas Jürgen

Seifert-Held Thomas

Sereinigg Michael

Simon Andrea

Stojakovic Tatjana

Täubl Philipp

Tscheliessnigg Karlheinz

Wiederstein-Grasser Iris

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Abstract:

Literature is controversial whether organs from living donors have a better graft function than brain dead (BD) and non-heart-beating donor organs. Success of transplantation has been correlated with high-energy phosphate (HEP) contents of the graft. HEP contents in heart, liver, kidney, and pancreas from living, BD, and donation after cardiac death in a pig model (n=6 per donor type) were evaluated systematically. BD was induced under general anesthesia by inflating a balloon in the epidural space. Ten hours after confirmation, organs were retrieved. Cardiac arrest was induced by 9V direct current. After 10min of ventricular fibrillation without cardiac output, mechanical and medical reanimation was performed for 30min before organ retrieval. In living donors, organs were explanted immediately. Freeze-clamped biopsies were taken before perfusion with Celsior solution (heart) or University of Wisconsin solution (abdominal organs) in BD and living donors or with Histidine-Tryptophan-Ketoglutaric solution (all organs) in non-heart-beating donors, after perfusion, and after cold ischemia (4h for heart, 6h for liver and pancreas, and 12h for kidney). HEPs (adenosine triphosphate, adenosine diphosphate, adenosine monophosphate, and phosphocreatine), xanthine, and hypoxanthine were measured by high-performance liquid chromatography. Energy charge and adenosine triphosphate-to-adenosine diphosphate ratio were calculated. After ischemia, organs from different donor types showed no difference in energy status. In all organs, a decrease of HEP and an increase in hypoxanthine contents were observed during perfusion and ischemia, irrespective of the donor type. Organs from BD or non-heart-beating donors do not differ from living donor organs in their energy status after average tolerable ischemia. Copyright © 2013 Elsevier Inc. All rights reserved.

Find related publications in this database (using NLM MeSH Indexing)

Adenosine Triphosphate - metabolism

Animals -

Brain Death -

Energy Metabolism -

Ischemia - metabolism

Kidney - metabolism

Liver - metabolism

Living Donors -

Myocardium - metabolism

Organ Transplantation -

Pancreas - metabolism

Swine -

Tissue Donors -

Find related publications in this database (Keywords)

Living donor

Brain dead donor

Non-heart-beating donor

High-energy phosphates

Heart

Liver

Kidney

Pancreas

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