Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Zanghellini, B; Grünewald, TA; Burghammer, M; Rennhofer, H; Liegl-Atzwanger, B; Leithner, A; Lichtenegger, HC.
High-resolution large-area imaging of nanoscale structure and mineralization of a sclerosing osteosarcoma in human bone.
J Struct Biol. 2019; 207(1):56-66
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Autor/innen der Med Uni Graz:
Leithner Andreas
Liegl-Atzwanger Bernadette
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Abstract:
Osteosarcoma is the most common primary bone cancer type in humans. It is predominantly found in young individuals, with a second peak later in life. The tumour is formed by malignant osteoblasts and consists of collagenous, sometimes also mineralized, bone matrix. While the morphology of osteosarcoma has been well studied, there is virtually no information about the nanostructure of the tumour and changes in mineralization on the nanoscale level. In the present paper, human bone tissue inside, next to and remote from a sclerosing osteosarcoma was studied with small angle x-ray scattering, x-ray diffraction and electron microscopy. Quantitative evaluation of nanostructure parameters was combined with high resolution, large area mapping to obtain microscopic images with nanostructure parameter contrast. It was found that the tumour regions were characterized by a notable reduction in mineral particle size, while the mineral content was even higher than that in normal bone. Furthermore, the normal preferential orientation of mineral particles along the longitudinal direction of corticalis or trabeculae was largely suppressed. Also the bone mineral crystal structure was affected: severe crystal lattice distortions were detected in mineralized tumour tissue pointing to a different ion substitution of hydroxyl apatite in tumorous tissue than in healthy tissue. Copyright © 2019 Elsevier Inc. All rights reserved.

Find related publications in this database (Keywords)
Osteosarcoma
Bone nanostructure
Bone matrix mineralization
X-ray scattering
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