Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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SHR Neuro Krebs Kardio Lipid

Smretschnig, E; Hagen, S; Gamper, J; Krebs, I; Binder, S; Ansari-Shahrezaei, S.
Long-term follow-up of half-fluence photodynamic therapy in acute central serous chorioretinopathy
SPEKTRUM AUGENHEILKD. 2018; 32(6): 215-222.
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Autor/innen der Med Uni Graz:
Ansari Shahrezaei Siamak

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Background To evaluate the long-termresults of indocyanine green angiography(ICGA)-guided verteporfin (Visudyne (R), Novartis, Basel, Switzerland) photodynamic therapy (PDT) with half-fluence rate in the treatment of acute symptomatic central serous chorioretinopathy (CSC). Material and methods A retrospective review was performed of 12 patients with acute symptomatic CSC verified by spectral-domain optical coherence tomography (SD-OCT) and fluorescein angiography (FA), treated with ICGA-guided verteporfin (6 mg/m(2))PDT with half-fluence rate (25 J/cm(2)). The vision-related quality of life (VR QOL) 25-Item National Eye Institute Visual Function Questionnaire (VFQ-25) was completed by all patients and 82 controls. Results Best corrected visual acuity (BCVA) at baseline was 77.5 (+/- 10; n=12) according to the Early Treatment Diabetic Retinopathy Study (EDTRS) letter score and changed to 89 letters (+/- 9.9; p=0.0003) at long-term follow-up (83.8 +/- 4.8 months after PDT). Baseline contrast sensitivity (CS) was 29.5 +/- 4.5 Pelli-Robson letters and increased to 34.5 +/- 4.5 letters at long term (p < 0.0006). Baseline central foveal thickness (CFT) was 419 mu m and decreased to 242 mu m at long term (p < 0.0001). The long-term vision-related quality of life of patients was similar to that of controls. Conclusion ICGA-guided half-fluence PDT with verteporfin results in excellent long-term visual improvement in BCVA and CS, a significant reduction of CFT, and high levels of VR QOL.

Find related publications in this database (Keywords)
Central serous chorioretinopathy
Indocyanine green angiography
Photodynamic therapy
National Eye Institute Visual Function Questionnaire
Long term outcome
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