Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Scholl, HP; Strauss, RW; Singh, MS; Dalkara, D; Roska, B; Picaud, S; Sahel, JA.
Emerging therapies for inherited retinal degeneration.
Sci Transl Med. 2016; 8(368):368rv6-368rv6
Web of Science PubMed FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Strauß Rupert
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Abstract:
Inherited retinal degenerative diseases, a genetically and phenotypically heterogeneous group of disorders, affect the function of photoreceptor cells and are among the leading causes of blindness. Recent advances in molecular genetics and cell biology are elucidating the pathophysiological mechanisms underlying these disorders and are helping to identify new therapeutic approaches, such as gene therapy, stem cell therapy, and optogenetics. Several of these approaches have entered the clinical phase of development. Artificial replacement of dying photoreceptor cells using retinal prostheses has received regulatory approval. Precise retinal imaging and testing of visual function are facilitating more efficient clinical trial design. In individual patients, disease stage will determine whether the therapeutic strategy should comprise photoreceptor cell rescue to delay or arrest vision loss or retinal replacement for vision restoration. Copyright © 2016, American Association for the Advancement of Science.
Find related publications in this database (using NLM MeSH Indexing)
Animals -
Clinical Trials as Topic -
Genetic Predisposition to Disease -
Genetic Therapy -
Humans -
Molecular Biology -
Optogenetics -
Photoreceptor Cells -
Retina - physiopathology
Retinal Degeneration - genetics
Retinal Degeneration - physiopathology
Retinal Degeneration - therapy
Stem Cell Transplantation -
Stem Cells - cytology
Vision, Ocular - physiology
Visual Prosthesis -

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