Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Hagen, S; Ansari-Shahrezaei, S; Smretschnig, E; Glittenberg, C; Krebs, I; Steiner, I; Binder, S.
Effect of photodynamic therapy on short-wavelength fundus autofluorescence in eyes with acute central serous chorioretinopathy.
Retina. 2015; 35(2):223-230
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Autor/innen der Med Uni Graz:
Ansari Shahrezaei Siamak
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Abstract:
To evaluate short-wavelength FAF as a parameter of retinal pigment epithelium function in eyes with acute symptomatic central serous chorioretinopathy after indocyanine green angiography-guided verteporfin photodynamic therapy with half-fluence rate. A retrospective review over a period of 1 year of short-wavelength FAF images of 15 consecutive patients treated with half-fluence rate (25 J/cm) indocyanine green angiography-guided verteporfin photodynamic therapy due to acute symptomatic central serous chorioretinopathy was performed. Short-wavelength (488 nm) FAF gray values were evaluated with a confocal scanning laser ophthalmoscope at a 350-μm diameter and a 1,200-μm diameter circle centered on the fovea. The change in short-wavelength (488 nm) FAF gray values for the 2 circles was evaluated by calculating the differences of respective values between the first month after treatment and the 3, 6, 9, and 12 months follow-up. Mean differences (95% confidence interval) in short-wavelength (488 nm) FAF gray values of the 350-μm and 1,200-μm diameter circle between the 1-month and the 3-month (n = 15) follow-up were -0.03 (-0.11 to 0.05) (P = 0.46) and -0.03 (-0.17 to 0.10) (P = 0.6). Respective differences between the 1 month and the 6 (n = 15), 9 (n = 14), and 12 months (n = 13) of follow-up were -0.03 (-0.11 to 0.05) (P = 0.42) and -0.04 (-0.16 to 0.08) (P = 0.5); -0.05 (-0.12 to 0.03) (P = 0.23) and -0.06 (-0.18 to 0.07) (P = 0.33); -0.03 (-0.12 to 0.07) (P = 0.57) and -0.07 (-0.20 to 0.05) (P = 0.22). Half-fluence rate (25 J/cm) indocyanine green angiography-guided verteporfin photodynamic therapy did not significantly affect short-wavelength FAF at a 350-μm diameter and a 1,200-μm diameter circle in eyes with resolved acute symptomatic central serous chorioretinopathy throughout 12 months of follow-up.
Find related publications in this database (using NLM MeSH Indexing)
Acute Disease -
Central Serous Chorioretinopathy - diagnosis
Central Serous Chorioretinopathy - drug therapy
Central Serous Chorioretinopathy - physiopathology
Coloring Agents -
Female -
Fluorescein Angiography -
Fundus Oculi -
Humans -
Indocyanine Green -
Male -
Middle Aged -
Optical Imaging -
Photochemotherapy -
Photosensitizing Agents - therapeutic use
Porphyrins - therapeutic use
Retinal Pigment Epithelium - physiopathology
Retrospective Studies -

Find related publications in this database (Keywords)
short-wavelength fundus autofluorescence
central serous chorioretinopathy
photodynamic therapy
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