Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Ivastinovic, D; Saliba, S; Ardjomand, N; Wedrich, A; Velikay-Parel, M.
Evaluation of limbal and pars plana silicone oil removal in aphakic eyes.
Acta Ophthalmol. 2011; 89(5): e417-e422. [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG


Autor/innen der Med Uni Graz:
Ardjomand Navid
Ivastinovic Domagoj
Thaler-Saliba Sarah
Velikay-Parel Michaela
Wedrich Andreas

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Plum Analytics:
Purpose: To compare limbal and pars plana silicone oil removal (SOR) in aphakic eyes and to evaluate the acute effect of silicone oil flow to the corneal endothelium. Methods: Sixteen aphakic patients with silicone oil endotamponade requiring SOR were recruited for this prospective study and randomly scheduled for limbal or pars plana SOR. The central corneal thickness (CCT), visual acuity (VA) and intraocular pressure were measured preoperatively, on the first postoperative day and 4 months after surgery. Endothelial cell density (ECD) was measured preoperatively and at the end of follow-up. The in vitro study was performed on ten enucleated porcine eyes. Corneoscleral discs were prepared and fixed on artificial anterior chamber followed by 2.5-mm limbal incision and 5-ml silicone oil injection in six cases and 5 ml balanced salt solution (BSS) in four cases. Results: The ECD decreased by 239.2 +/- 86.7 (13.9%) and 86.7 +/- 22.4 cells /mm(2) (5%) after limbal (n = 8) and pars plana SOR (n = 8), respectively (p < 0.001 for both). The difference between the groups was significant (p < 0.001). A significant increase in CCT and corresponding decrease in VA was noted on the first postoperative day using both procedures. At the end of follow-up, the CCT and VA were comparable to initial values. Postoperative hypotony (<= 6 mmHg) was observed more frequently after limbal SOR. In the experiment, lamellar abrasions of corneal endothelium were observed after silicone oil injection, whereas no changes were observed after BSS injection. Conclusion: Limbal SOR causes more considerable damage to the corneal endothelium than the pars plana approach because of mechanical abrasion.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Aged -
Animals -
Aphakia - metabolism Aphakia - surgery
Cell Count -
Endotamponade - adverse effects Endotamponade - methods
Endothelium, Corneal - drug effects Endothelium, Corneal - metabolism Endothelium, Corneal - pathology
Female -
Humans -
Limbus Corneae - surgery
Male -
Middle Aged -
Pars Planitis - surgery
Postoperative Complications - etiology Postoperative Complications - pathology
Prospective Studies -
Silicone Oils - adverse effects Silicone Oils - pharmacokinetics
Stress, Mechanical -
Swine -
Swine, Miniature -

Find related publications in this database (Keywords)
central corneal thickness
corneal endothelium
endothelial cell density
pars plana
porcine eyes
silicone oil removal
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